Development of Mulberry Leaf Extract for Suppressing Postprandial Blood Glucose Elevation

Kimura, Toshiyuki

doi:10.5772/24893

Cited by 9 publications

(9 citation statements)

References 36 publications

(41 reference statements)

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“…Overweight and older subjects were excluded to minimize the risk of recruiting individuals with (undiagnosed) impaired glucose tolerance. Subjects were therefore selected in the age range 20-50 yr, with a body mass index (BMI) in the "normal" range (18)(19)(20)(21)(22)(23)(24)(25) according to the World Health Organization guidance [18]. The complete inclusion and exclusion criteria are described in the Supplementary Material, Table S1.…”

Section: Participantsmentioning

confidence: 99%

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial

et al. 2020

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Background: Lower post-prandial glucose (PPG) and insulin (PPI) responses to foods are associated with reduced diabetes risk and progression. Several plant extracts have been proposed to reduce PPG or PPI by inhibiting enzymes or transporters involved in carbohydrate digestion and uptake. This study evaluates a range of such extracts, consumed with a carbohydrate load, for their effects on PPG, PPI and indicators of (gastrointestinal) tolerance. Methods: Interventions were extracts of mulberry fruit (MFE, 1.5 g), mulberry leaf (MLE, 1.0 g), white bean (WBE, 3.0 g), apple (AE, 2.0 g), elderberry (EE, 2.0 g), turmeric (TE, 0.18 g), AE + TE, and EE + TE. Each of these 8 individual extracts or combinations were added to a rice porridge containing~50 g available carbohydrate (control). In a within-subject (randomised, balanced incomplete block) design, individual subjects received the control and a subset of 4 of the 8 extracts or combinations. Participants were 72 apparently healthy adults (mean [SD] age 31.2 [5.5] yr, body mass index 22.1 [2.0] kg/m 2). The primary outcome was the percentage change in 2-h PPG (positive incremental area under the curve) relative to control. Secondary measures were the 2-h PPI response, 7-h breath hydrogen, measures of gastrointestinal discomfort, and urine glucose. Results: In the 65 subjects who completed the control and at least one intervention treatment, additions of AE, MFE and MLE produced statistically significant reductions in PPG vs control (p < 0.05; mean effect − 24.1 to − 38.1%). All extracts and combinations except TE and WBE significantly reduced PPI (p < 0.01; mean effect − 17.3% to − 30.4%). Rises in breath hydrogen > 10 ppm were infrequent, but statistically more frequent than control only for MLE (p = 0.02). Scores for gastrointestinal discomfort were extremely low and not different from control for any treatment, and no glucosuria was observed.

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Section: Participantsmentioning

confidence: 99%

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial

et al. 2020

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“…According to Kimura et al (2011), the amount of DNJ in mulberry leaves is 0.1% to 0.2% (Kimura et al 2011), corresponding to approximately 5 mg of DNJ in 5 g of mulberry leaves per weekly feed used in this study. DNJ, which is present in large quantities in mulberry leaves and silkworms, has been shown to inhibit hepatitis virus (Carrouée et al 2001;Jacob et al 2007), human immunodeficiency Figure 4 Comparison of the larvae group of non-treatment (left) and 5% mulberry treatment (right), the second larvae which fad fermented sawdust or 5% mulberry leaf powder.…”

Section: Discussionmentioning

confidence: 99%

“…According to Kimura et al . (), the amount of DNJ in mulberry leaves is 0.1% to 0.2% (Kimura et al . ), corresponding to approximately 5 mg of DNJ in 5 g of mulberry leaves per weekly feed used in this study.…”

Section: Discussionmentioning

confidence: 99%

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A role of mulberry leaves in improving resistance to virus‐mediated disease in Allomyrina dichotoma

Kwak

Han

Kim

et al. 2020

Entomological Research

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The purpose of this study was to develop a safe and effective method for preventing Allomyrina dichotoma nudivirus (AdNV) infection in the Korean horned beetle, Allomyrina dichotoma, found on the farms in the Republic of Korea. Mulberry leaf powder was added to fermented oak sawdust to minimize mortality in AdNV‐infected A. dichotoma. Mulberry leaves were found to contain 1‐deoxynojirimycin, which has anti‐inflammatory, antiviral, and anti‐tumor effects. Based on the proposed antiviral effects of mulberry leaves, a feed of fermented sawdust combined with 1% or 5% mulberry leaf powder was fed to AdNV‐infected second or third stage A. dichotoma larvae. The larval mortality rate was recorded over 10 weeks. The second and third instar larvae that were fed with the sawdust mixture with 5% mulberry leaf powder had mortality rates of 60% and 30%, respectively. In contrast, the control group that was fed with the sawdust without mulberry leaf powder had a mortality rate of 100%. Also, we confirmed that AdNV was not detected in the experimental group that was subjected to an outdoor application test for 8 months with mulberry leaf powder treatment. A reduced mortality rate after treatment with 1% mulberry leaf powder was observed in the field application. In addition, a comparison of the control colony and mulberry leaf treated group showed a statistical difference in growth of larvae at various states, and demonstrated the efficiency of mulberry leaf powder combined with fermented sawdust for treatment of AdNV‐ infected A. dichotoma.

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“…14 These mulberry alkaloids, especially M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 6 1-deoxynojirimycin (DNJ), decrease α-glucosidase activity by competitive inhibition through binding to the enzyme active site to mimic natural substrates. 15 DNJ-enriched mulberry extract may be useful in controlling postprandial hyperglycemia in pre-diabetic or mild diabetic individuals. 16 Oral administration of 0.24% DNJ and its derivatives was found to inhibit absorption of sucrose and polysaccharides in human and rat intestinal tissue samples.…”

Section: Alkaloidsmentioning

confidence: 99%

Current anti-diabetes mechanisms and clinical trials using Morus alba L.

Tian

Tang

Zhao

2016

Journal of Traditional Chinese Medical Sciences

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Development of Mulberry Leaf Extract for Suppressing Postprandial Blood Glucose Elevation

Cited by 9 publications

References 36 publications

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial

A role of mulberry leaves in improving resistance to virus‐mediated disease in Allomyrina dichotoma

Current anti-diabetes mechanisms and clinical trials using Morus alba L.

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