Current anti-diabetes mechanisms and clinical trials using Morus alba L.

Tian, Simin; Tang, Mingmin; Zhao, Baosheng

doi:10.1016/j.jtcms.2016.04.001

Cited by 21 publications

(17 citation statements)

References 59 publications

(47 reference statements)

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“…1-dexoynojirimycin (DNJ), flavonoids and polysaccharides from mulberry leaf are validated to have hypoglycemic effect through inhibition of α-glucosidase [3]. Mulberry leaf extract could increase insulin sensitivity by activating phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) signalling pathway via the translocation of the glucose transporter 4 (GLUT4) to the plasma membrane and the increase in expressions of pancreatic duodenal homeobox-1 (PDX-1), insulin-1, and insulin-2 in the pancreas, and correct the imbalance of glucose metabolism by activating AMP-activated protein kinase (AMPK) signalling with the uptake of 3-O-methyl-D-glucose transport [4]. Mulberry leaf could attenuate IR by enhancing the expression of the peroxisome proliferator-activated receptor γ (PPARγ), and it also could reduce oxidative stress and suppress the apoptosis of β-cell and nuclear factor kappa B (NF-κB) signalling pathway to improve IR [4].…”

Section: Introductionmentioning

confidence: 99%

Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

Tian

Wang

Liu

et al. 2019

BMC Complement Altern Med

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BackgroundIt has been testified that Diabetes mellitus (DM) has a close association with chronic inflammation and Toll-like Receptors (TLRs), and DM could be prevented by mulberry leaf. Therefore, a hypothesis came into being that mulberry leaf could ameliorate proinflammation and insulin resistance (IR) through TLRs and insulin signalling pathways.MethodsWater extracts of mulberry leaf (WEM) was given to diabetic mice by gavage for 10 weeks, and the diabetic mice was injected with low-dose streptozocin, fed with high-fat and high-sugar diet. Oral glucose tolerance tests (OGTTs) were conducted. At the same time, homeostasis model assessment of insulin (HOMA-IR) and the level of the inflammatory factor, tumour necrosis factor-α (TNF-α) was measured. The expressions of critical nodes of TLRs and insulin signalling pathway were also examined.ResultsWEM contributed to a significant decrease in fasting blood glucose, AUC from the investigation of OGTTs and HOMA-IR. The levels of the inflammatory factor, tumour necrosis factor-α (TNF-α) also declined. Moreover, WEM suppressed the expression of TLR2, myeloid differentiation primary-response protein 88 (MyD88), tumour-necrosis-factor receptor-associated factor 6 (TRAF6), nuclear factor kappa B (NF-κB) in the skeletal muscle. WEM could up-regulate the expression of insulin receptor (InsR) and insulin receptor substrate 1 (IRS1), and down-regulate the phosphorylation of IRS1 in adipose tissue.ConclusionThrough this study, a conclusion could be made that WEM mitigates hyperglycemia, IR, and inflammation through the interactions among TLR2 signalling pathway, insulin signalling pathway and TNF-α.

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Section: Introductionmentioning

confidence: 99%

Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

Tian

Wang

Liu

et al. 2019

BMC Complement Altern Med

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“…Mori Folium (MF), known as Sangye (Pinyin name) in Chinese, is the dried leaf derived from Morus alba L., which has been widely used for more than 1000 years in Chinese medicine clinics and other Asian countries (Tian et al, 2016 ). According to Chinese Pharmacopeia (2015 version), MF is yearly harvested at the First Frost and recognized as an edible herb with the function of clearing heat and eliminating cough as well as invigorating liver and improving eyesight in combination with other herbs.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats

et al. 2018

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Purpose: The present study is aimed to explore whether the aqueous extract of Mori Folium (MF) exhibits bone protective effect by regulating calcium and redox homeostasis in diabetic rats, and to identify the signaling pathways involved in this process.Methods: Diabetic rats were established using high-sugar and high-fat diet and streptozotocin (STZ) (30 mg/kg for 3 consecutive days). The serum levels of osteocalcin (OC), insulin-like growth factor-1 (IGF-1), tartrate-resistant acid phosphatase (TRAP), phosphorus (P), calcium (Ca), 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], parathormone (PTH), advanced glycation end products (AGEs), superoxide dismutase (SOD), and malondialdehyde (MDA), total antioxidant capacity (TAC), 8-hydroxy-2′-deoxyguanosine (8-OH-dG), and interleukin 6 (IL-6) were determined by ELISA or biochemical assays. Histopathological alterations in the femurs were evaluated by the stainings of hematoxylin-eosin (H&E) and alizarin red S. In addition, femoral strength was detected by a three-point bending assay, bone microstructure was detected with micro-computer tomography. Bone material properties were examined by Fourier-transform infrared spectroscopy. Furthermore, the expressions of IGF-1, runt-related transcription factor 2 (Runx2), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL), cathepsin K, AGEs, receptor of advanced glycation end products (RAGE), NADPH oxidase 4 (Nox4), and nuclear factor kappa-B (NF-κB) in the femurs and tibias, and the alterations in the levels of calcium-binding protein-28k (CaBP-28k), transient receptor potential V6 (TRPV6), and vitamin D receptor (VDR) in the kidneys and duodenums were determined by western blot and immunohistochemical analysis.Results: Treatment of diabetic rats with MF aqueous extract induces an increase in the levels of OC and IGF-1 as well as a decrease in TRAP level in serum. MF treatment also upregulates the expression of OPG, downregulates the expressions of AGEs, RAGE, Nox4, NF-κB, and RANKL, which leads to improve bone microstructure and strength exhibited by an increase in cortical area ratio, cortical thickness, and trabecular area ratio as well as ultimate load, elastic modulus, and bending stress in the femurs and tibias of diabetic rats. In addition, MF aqueous extract preserves bone material properties by decreasing the ratio of fatty acid/collagen and increasing the ratio of mineral/matrix in the femurs of diabetic rats. Moreover, MF treatment increases the levels of P, Ca, and 1,25(OH)2D3, and decreases the level of PTH in the serum, as well as upregulates the expressions of TRPV6 and VDR in the duodenums and CaBP-28k in the kidneys of diabetic rats. Additionally, MF has ability of rebuilding redox homeostasis and eliminating inflammatory stress by increasing the levels of SOD and TAC as well as decreasing the levels of IL-6, AGEs, MDA, and 8-OH-dG.Conclusions: MF treatment may improve bone quality through maintenance of calcium homeostasis via regulating the PTH/VDR/CaBP signaling, and elimination of ox...

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“…Similarly, in cells and animal studies, it was found that preparations and active compounds from Morus sp. have inhibitory effects on gene expression of all regulatory GNG enzymes, including phosphoenolpyruvate carboxykinase (PEPCK) [133,134].…”

Section: Effects On Glucose Homeostasis In the Livermentioning

confidence: 99%

Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

Nashar¹,

Kiselova-Kaneva²,

Ivanova³

2019

Nutrition in Health and Disease - Our Challenges Now and Forthcoming Time

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The idea of this chapter is that currently available antidiabetic drugs specifically target several points of the T2D pathophysiology but they do not cover all aspects of the disease. In addition, many adverse effects of synthetic antidiabetic agents have been reported. The suggested manuscript is an overview of the available scientific literature focused on antiobesity and antidiabetic potential of selected 42 medicinal and edible plants of the Bulgarian flora. Most of the reports reveal the effect of extracts or their active components on specific biochemical mechanisms. Mechanistic data about hypoglycemic and hypolipidemic action are presented for some of the plants. An essential part of this review is dedicated to the target mechanisms behind the effects of the selected plant species. The authors hope that this review will serve as a starting point for future investigations with a contribution to the prevention and therapy of diabetes.

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Current anti-diabetes mechanisms and clinical trials using Morus alba L.

Abstract: Backgrounds: Diabetes mellitus, especially type 2 diabetes, with its fast-rising

Cited by 21 publications

References 59 publications

Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats

Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

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