Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug release study and antibacterial activity

Abstract

Periodontitis is one of the most widespread oral diseases. Medicated in-situ gels of Moxifloxacin Hydrochloride for extended period of retention in infected cavity were prepared for improved local action for the treatment of periodontitis. Medicated formulations were prepared using temperature sensitive (poloxamer 407), ion sensitive (gellan gum) and pH sensitive (carbopol 934P) polymers. 32 Full Factorial Design has been applied and prepared batches were characterized by FTIR, pH, syringeability, drug content, clarity, gelation temperature, gelling time, in-vitro gelling capacity, in-vitro diffusion study. Gelation temperature, (in-vitro) gelling time and the nature of gel formed in simulated saliva showed polymeric concentration dependency. Diffusion study of in-situ gel had been performed which showed augmented arrival of medication from 7-12 hours and the discharge was dependent on polymer utilized. The best fitted model was zero order kinetics which indicated that the formulation gave controlled delivery. All preparations were non-Newtonian and display pseudoplastic conduct. Invitro Antimicrobial study was carried out by utilizing E. coli and S. aureus. Optimized formulation containing 19.072 %w/v poloxamer 407 and 0.245 %w/v gellan gum exhibited desired characteristics for developing periodontal drug delivery systems.

In vitro–in vivo evaluation of tetrahydrozoline‐loaded ocular in situ gels on rabbits for allergic conjunctivitis management

“…In this study, the cold method was applied for the preparation of the thermosensitive in situ gels of THZ. Besides, there are also other methods as the hot process which, however, leads to undesirable physiochemical effects as the formation of polymeric lumps (Swain, Patel, Gandhi, & Shah, 2019). There are various polymers which are used for the preparation of the in situ gels, either natural or synthetic (Güven, Berkman, Şenel, & Yazan, 2019; Üstündağ Okur et al, 2019).…”

Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

“…As can be seen from the table, the hardness value of the gels increased significantly as the PLX 407 ratio increased. Similarly, Swain et al expressed that the hardness of the formulation increases as the concentration of polymer increases for their in situ gel formulations [35]. Although the hardness value was increased, it was observed that this value did not adversely affect the application and spreading of the formulation.…”

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

“…Recently, in situ gel formulation for local delivery moxifloxacin hydrochloride in periodontal disease has been developed by Swain et al [ 95 ]. The gel formulations were prepared using thermally-sensitive (Poloxamer 407), ion-sensitive (Gellan gum), and pH-sensitive (Carbopol 934P) polymers.…”