Development of modified method for quantification of regional myocardial blood flow using 15O-water with PET

Katoh, Chietsugu; Morita, Koichi; Nakada, Kunihiro; Tamaki, Nagara

doi:10.1016/j.ics.2004.04.011

Cited by 27 publications

(42 citation statements)

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“…MBF was analyzed by a semiautomatic program as previously reported [28]. The frames of the water image were summed and the blood volume image (CO) was then subtracted to generate a myocardial uptake image.…”

Section: O-watermentioning

confidence: 99%

Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET

Yoshinaga

Manabe

Katoh

et al. 2010

Eur J Nucl Med Mol Imaging

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Section: O-watermentioning

confidence: 99%

Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET

Yoshinaga

Manabe

Katoh

et al. 2010

Eur J Nucl Med Mol Imaging

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“…4 × 2.4 mm). MBF PET was quantified (mL/min/g) using software developed in-house with left ventricular (LV ) chamber and LV myocardium ROIs [18]. MBF PET was quantified as previously described [18][19][20].…”

Section: Quantification Of Mbf Petmentioning

confidence: 99%

“…Quantitative MBF CT was calculated using a single-tissue compartment model with the Renkin-Crone equation [10,[18][19][20] (See Appendix).…”

Section: Ctp Image Reconstruction and The Formula To Obtain Mbf Ctmentioning

confidence: 99%

Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET

et al. 2014

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Objectives: This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against 15 O-H 2 O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.Methods: Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs of CTP and PET obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7).Results: Correlation between MBF of MDCT and PET was strong (r = 0.95, p<0.0001).CFR showed good correlation between dynamic CTP and PET (r = 0.67, p = 0.0126).CFR CT in the CAD group (2.3 ± 0.8) was significantly lower than that of in the validation group (5.2 ± 1.8) (p = 0.0011).Conclusion: We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP. Key Points MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. MBF and CFR showed good correlation between dynamic CTP and PET. Lower CFR was well demonstrated in CAD patients by dynamic CTP.

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“…After a 6-minute interval, a slow adenosine infusion for 9 minutes at the rate of 0.16 mg/kg/min was initiated. The second dynamic scan of 24 frames for hyperemic MBF was started 3 minutes later [28,32,33].…”

Section: I-bmipp-spectmentioning

confidence: 99%

“…Rest MBF and hyperemic MBF and MFR were calculated by a program developed by Katoh et al [28,32,33]. In brief, the program automatically divides the left ventricular wall into 13 regions of interest (ROIs) as shown in Figure 1 …”

Section: Calculation Of Mbf and Mfrmentioning

confidence: 99%

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

Kageyama

Morita

Katoh

et al. 2005

Eur J Nucl Med Mol Imaging

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Long-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest. In ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123 I-BMIPP is a radiolabeled LCFA analogue. In chronic stable angina without previous infarction, we suppose that reduced 123 I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). Conclusion: In chronic stable angina without previous infarction, reduced 123 I-BMIPP uptake implies decreased MFR.

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Development of modified method for quantification of regional myocardial blood flow using 15O-water with PET

Cited by 27 publications

References 0 publications

Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET

Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET

Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET

Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

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