Development of methotrexate-loaded cubosomes with improved skin permeation for the topical treatment of rheumatoid arthritis

Janakiraman, Kumar; Krishnaswami, Venkateshwaran; Sethuraman, Vaidevi; Rajendran, Vijaya; Kandasamy, Ruckmani

doi:10.1007/s13204-019-00976-9

Cited by 32 publications

(6 citation statements)

References 69 publications

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“…This selective cytotoxicity reduces the potential side effects of the drug, highlighting the targeted drug delivery and its subsequent cytotoxic effect. Overall, this study concluded that GMO-AT101 cubosomes present a promising alternative for the treatment of GBM [57].…”

Section: H A101mentioning

confidence: 61%

Cubosome: A Potential Nanocarrier in Cancer Therapy

et al. 2023

IJFMR

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Section: H A101mentioning

confidence: 61%

Cubosome: A Potential Nanocarrier in Cancer Therapy

et al. 2023

IJFMR

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“…Vesicles, such as distributed nanoparticles of lamellar liquid-crystalline phase or vesicle-like structures, always coexist with cubosomes created via the top-down approach. At high oscillation frequencies, cubic phases become relatively elastic [ 43 ].…”

Section: Methods Of Preparationmentioning

confidence: 99%

Cubosomes in Drug Delivery—A Comprehensive Review on Its Structural Components, Preparation Techniques and Therapeutic Applications

2023

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Cubosomes are lipid vesicles that are comparable to vesicular systems like liposomes. Cubosomes are created with certain amphiphilic lipids in the presence of a suitable stabiliser. Since its discovery and designation, self-assembled cubosomes as active drug delivery vehicles have drawn much attention and interest. Oral, ocular, transdermal, and chemotherapeutic are just a few of the drug delivery methods in which they are used. Cubosomes show tremendous potential in drug nanoformulations for cancer therapeutics because of their prospective advantages, which include high drug dispersal due to the structure of the cubic, large surface area, a relatively simple manufacturing process, biodegradability, ability to encapsulate hydrophobic, hydrophilic, and amphiphilic compounds, targeted and controlled release of bioactive agents, and biodegradability of lipids. The most typical technique of preparation is the simple emulsification of a monoglyceride with a polymer, followed by sonication and homogenisation. Top-down and bottom-up are two different sorts of preparation techniques. This review will critically analyse the composition, preparation techniques, drug encapsulation approaches, drug loading, release mechanism and applications relevant to cubosomes. Furthermore, the challenges faced in optimising various parameters to enhance the loading capacities and future potentialities are also addressed.

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“…83 Poloxamer 188-based cubosomes were recently prepared for methotrexate skin delivery in rheumatoid arthritis using the high-pressure homogenization technique. 84 The water-soluble, non-ionic tri-block copolymer of polypropylene and polyethylene oxide functions as both a surfactant and a penetration enhancer by increasing the thermodynamic coefficient of the drug, leading to the emulsification of sebum, and is used extensively in thermosensitive hydrogels for nasal, vaginal, and ocular mucous membrane administration. 85 A combination of poloxamer 188 and poloxamer 407 was used to develop cubosomes for intranasal and intraperitoneal administration in diabetes treatment.…”

Section: Cubosomes -A Potential Vehicle For Drug Deliverymentioning

confidence: 99%

“…Thus, the overall results demonstrated that the topical use of MTCs may be a potential therapy for the management of rheumatoid arthritis. 84 By employing the 'quality by design' (QbD) methodology, the proposed study of Rapalli et al intended to generate topically delivered hydrogels comprising ketoconazole-based cubosomes using a lower surfactant concentration. Following a risk assessment, the formulations were screened and optimized using the Design-Expert s software 3 2 factorial design.…”

Section: Topical Routementioning

confidence: 99%