Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids

Abstract

Three polyvinylchloride (PVC) membrane sensors for the determination of moexipril hydrochloride were prepared and characterized. The sensors are based on the use of the ion association complexes of moexipril cation with either ammonium reineckate (sensor 1) or tetraphenyl borate (sensor 2) or phosphotungistic acid (sensor 3) counter anions as ion exchange sites in the PVC matrix. The performance characteristics of these sensors were evaluated according to IUPAC recommendations, which reveal a fast, stable and linear response for moexipril over the concentration range of 10 -6 to 10 -2 M for the three sensors with cationic slopes of 29.1, 30.1 and 30.2 mV per concentration decade for the three sensors, respectively. The direct potentiometric determination of moexipril hydrochloride using the proposed sensors gave recoveries % of 99.64 ± 0.34, 99.34 ± 0.56 and 99.68 ± 0.42 for the three sensors, respectively. The sensors were used for determination of moexipril hydrochloride in pharmaceutical formulations and in plasma. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of moexipril hydrochloride. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.

Structural identification of degradants of moexipril by LC–MS/MS

“…Moexipril is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor, used for the treatment of hypertension and congestive heart failure (Belal, Metwaly, & Amer, 2009). Moexipril can be administered alone or in combination with other antihypertensives or diuretics (Belal et al, 2009). It acts by inhibiting the conversion of angiotensin I to angiotensin II.…”

Synchronized separation of seven medications representing most commonly prescribed antihypertensive classes by using reversed‐phase liquid chromatography: Application for analysis in their combined formulations

“…Moexipril hydrochloride (MXP), (3 S )‐2‐[(2 S )‐ 2 ‐{[(1 S )‐ 1 ‐(ethoxycarbonyl)‐ 3 ‐phenylpropyl]amino}‐1‐oxopropyl]‐6, 7‐dimethoxy‐1, 2, 3, 4‐tetrahydroisoquinoline‐3‐carboxylic acid hydrochloride (Fig. E), is a new potent orally active nonsulfhydryl angiotensin‐converting‐enzyme inhibitor for the treatment of hypertension and congestive heart failure . Aliskiren hemifumarate (ALS), 2( S ),4( S ),5( S ),7( S )‐ N ‐(2‐carbamoyl‐2‐methylpropyl)‐5‐amino‐4‐hydroxy‐2,7‐diisopropyl‐8‐[4‐methoxy‐3‐(3‐methoxypropoxy)phenyl]octanamide hemifumarate (Fig.…”

Spectrophotometric and Chemometric Methods for Simultaneous Determination of Two Anti-Hypertensive Drugs in their Combined Dosage Form

“…Spectroscopic [8][9][10], High Performance Liquid Chromatography (HPLC) [11][12][13], Thin Layer Chromatography (TLC) [14], Electrochemical [15][16][17] and mass spectrometry [18] methods for estimation of MOX alone or in combination with other drugs in pharmaceutical preparation have been reported. Hydrochlorothiazide alone or in combination with other drugs is estimated by HPLC [19][20][21][22][23][24][25][26][27][28][29], TLC-densitometry [30][31][32][33][34][35][36], capillary electrophoresis [37][38][39], electrochemical [40][41][42][43] and spectroscopic methods [44][45][46][47][48][49][50][51][52][53].…”