Development of magnetically targeted drug delivery system using superconducting magnet

Takeda, Shin‐ichi; Mishima, Fumihito; Fujimoto, Suketaka; Izumi, Yoshinobu; Nishijima, Shigehiro

doi:10.1016/j.jmmm.2006.10.1195

Cited by 108 publications

(77 citation statements)

References 8 publications

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“…These magnetic fields have been found to penetrate the skin surface to a depth of 20 mm. 125 Further, neodymium-iron-boron has been used along with SPIONs to enhance magnetic drug targeting. 58,59 Magnetic stents or implants, which can create strong local magnetic fields, have also been used to increase the concentration of drug-loaded magnetic nanoparticles at the desired site.…”

Section: Pitfalls Of Using Spions As Drug Delivery Vehiclesmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

891

574

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Section: Pitfalls Of Using Spions As Drug Delivery Vehiclesmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

891

574

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“…. A targeting depth of 5cm has been examined in human body using magnetic particles of 100nm size as the carriers and magnetic field of 0.2-0.8 T 24,30 . Moreover, targeting depth has increased to 12cm in animal experiments with larger carriers (500nm-5 mm) and 0.5 T magnetic field 25 .…”

Section: Introductionmentioning

confidence: 99%

“…Maximum depth of targeting being attained in human body is 5cm 24,38 . Therefore, increasing depth of magnetic targeting is still a challenging desire for tumor therapies [43][44][45] .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Utilization of Nanowires Instead of Spherical Particles on Magnetic Drug Targeting

Za¹,

Baniasadi²,

Asadi³

et al. 2017

Preprint

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Magnetic drug targeting can be used for locoregional cancer therapy, although the limitation is minuteness of the induced force. A new and simple procedure to enhance the magnetic force is changing the shape of carrier particles. It has been mathematically proved that exerting much stronger magnetic dipoles to nanowires are more possible than to spheres with the same volume. The magnetic dipole of wires having aspect quotient (ratio of length to diameter) of 3 is higher than the spheres of the same volume. Nanowires with α = 5 have magnetic dipoles 1.95 times greater than spheres with the same volume. At a fixed radius, the magnetic dipole increases with volume of the drug carrier. Magnetic targeting depth is an important parameter depending on the aspect quotient α of particles. Calculations show that the depth of targeting can exceed 8.5 cm if a nanowire with 15 nm radius and length larger than 150 nm is used as the drug carrier. This depth is 1.7 times more than that reported by previous authors for spherical particles with the same-volume.

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“…Most of swimming approaches consequently rely upon magnetic fields to wirelessly transmit power to the microrobot. This proof-of-concept was first studied using electromagnets [1] and superconducting magnets [2], [3] in phantom devices. Rapidly, magnetic manipulation of therapeutic ferromagnetic nanoparticles (magnetic drug delivery) has progressed from animal to human clinical trials for shallow targets.…”

Section: Introductionmentioning

confidence: 99%

Control of a magnetic microrobot navigating in microfluidic arterial bifurcations through pulsatile and viscous flow

Belharet

Folio

Ferreira

2012

2012 IEEE/RSJ International Conference on Intelligent Robots and Systems

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Abstract-Navigating in bodily fluids to perform targeted diagnosis and therapy has recently raised the problem of robust control of magnetic microrobots under real endovascular conditions. Various control approaches have been proposed in the literature but few of them have been experimentally validated. In this paper, we point out the problem of navigation controllability of magnetic microrobots in high viscous fluids and under pulsatile flow for endovascular applications. We consider the experimental navigation along a desired trajectory, in a simplified millimeter-sized arterial bifurcation, operating in fluids at the low-Reynolds-number regime where viscous drag significantly dominates over inertia. Different viscosity environments are tested under a systolic pulsatile flow compatible with heart beating. The control performances in terms tracking, robustness and stability are then experimentally demonstrated.

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Development of magnetically targeted drug delivery system using superconducting magnet

Cited by 108 publications

References 8 publications

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

The Effect of Utilization of Nanowires Instead of Spherical Particles on Magnetic Drug Targeting

Control of a magnetic microrobot navigating in microfluidic arterial bifurcations through pulsatile and viscous flow

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