Development of magnetic ytterbium oxide core–shell particles for selectively trapping phosphopeptides

Meisenbichler, Christina; Rauch, Julia S.; Güzel, Yüksel; Wernig, Eva-Maria; Schemeth, Dieter; Tribus, Martina; Tessadri, Richard; Rainer, Matthias

doi:10.1039/c5ay03423j

Cited by 6 publications

(2 citation statements)

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“…Although immobilized metal affinity chromatography (IMAC) and metal oxide affinity chromatography (MOAC) are standardly used for their purification, several magnetic materials exploiting this powerful affinity were reported [ 184 , 185 ]. Similar mechanism is used also for separation of phosphorylated protein/peptides [ 186 , 187 ].…”

Section: Magnetic Nanoparticles In the Real Worldmentioning

confidence: 99%

Magnetic Nanoparticles: From Design and Synthesis to Real World Applications

et al. 2017

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The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired size, morphology, chemical composition, and surface chemistry. Physical and chemical stability of magnetic materials is acquired by the coating. Moreover, surface layers of polymers, silica, biomolecules, etc. can be designed to obtain affinity to target molecules. The combination of the ability to respond to the external magnetic field and the rich possibilities of coatings makes magnetic materials universal tool for magnetic separations of small molecules, biomolecules and cells. In the biomedical field, magnetic particles and magnetic composites are utilized as the drug carriers, as contrast agents for magnetic resonance imaging (MRI), and in magnetic hyperthermia. However, the multifunctional magnetic particles enabling the diagnosis and therapy at the same time are emerging. The presented review article summarizes the findings regarding the design and synthesis of magnetic materials focused on biomedical applications. We highlight the utilization of magnetic materials in separation/preconcentration of various molecules and cells, and their use in diagnosis and therapy.

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Section: Magnetic Nanoparticles In the Real Worldmentioning

confidence: 99%

Magnetic Nanoparticles: From Design and Synthesis to Real World Applications

et al. 2017

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“…1,[44][45][46][47] Recently, IMAC and MOAC materials containing these rare earth elements were also developed. 1,31,38,[48][49][50][51] Using magnetic microparticles as the support, prepared an IMAC material by chelating Ce 4+ ions on magnetic microspheres with IDA and determined that these materials exhibited better enrichment capacity compared to Fe 3+ chelated magnetic microspheres. 52 In another study using cerium(IV) ions, attached Ce 4+ ions to Fe 3 O 4 @SiO 2 supports via poly (vinylphosphonic acid) (PVPA) and found the IMAC material to allow a rapid and selective determination of phosphopeptides in bio-molecules, thanks to the abundance of Ce 4+ ions in the structure.…”

Section: Introductionmentioning

confidence: 99%