Development of magnetic force-assisted gene transfer system using biopolymer-coated ferromagnetic nanoparticles

Takeda, Shin‐ichi; Mishima, Fumihito; Terazono, Bungo; Izumi, Yoshinobu; Nishijima, Shigehiro

doi:10.1016/j.stam.2006.02.009

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…Again, the same geometry was used, and fluid velocity, vessel diameter, and nanoparticle diameter were set to 20 cm∕s , 2mm , and 2 m , respectively. The CE of carrier particles in the present results and Takeda et al (2006) are 70% and 65%, respectively (see Table 2). There are two reasons for this deviation.…”

Section: Validationsupporting

confidence: 59%

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Effect of Particle–Particle and RBC–Particle Interactions on Capture Efficiency of Magnetic Nanocarriers Under the Influence of a Nonuniform Magnetic Field

Lahonian,

Khedri,

Aminian

et al. 2023

Iran J Sci Technol Trans Mech Eng

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In this study, the capture efficiency (CE) of magnetic carrier particles at the region of interest (ROI) in a micro-vessel was investigated. A nonuniform magnetic field produced by a Nd-Fe-B magnet was applied to capture the carrier particles at the ROI. The particle–particle and red blood cell (RBC)–carrier particle interactions were taken into account. Other parameters including carrier particle diameter, magnetic force, and non-Newtonian behavior of blood were also considered. The finite element method was used to solve the governing equations. Four cases were considered: (1) Newtonian without interaction forces, (2) Newtonian with interaction forces, (3) non-Newtonian without interaction forces, and (4) non-Newtonian with interaction forces. The results showed that for a particle diameter of 2000 nm, the CE values for the case without interaction force and with interaction force were 70% and 53%, respectively. It was found that by considering the particle–particle and RBC–carrier particle interactions for all magnet–vessel distances, the CE of carrier particles decreased, on average, by nearly 19%. At a magnet–vessel distance of 2.5 cm ($$d=2.5\,\mathrm{cm}),$$ d = 2.5 cm ) , it was seen that the CE values for case 2 and case 3 were nearly 70% and 45%, representing the maximum and minimum CE values, respectively.

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Section: Validationsupporting

confidence: 59%

“…As can be seen, there is good agreement between both works. In addition, the present work is validated by the experimental work done by Takeda et al (2006). Again, the same geometry was used, and fluid velocity, vessel diameter, and nanoparticle diameter were set to 20 cm∕s , 2mm , and 2 m , respectively.…”

Section: Validationmentioning

confidence: 89%

Effect of Particle–Particle and RBC–Particle Interactions on Capture Efficiency of Magnetic Nanocarriers Under the Influence of a Nonuniform Magnetic Field

Lahonian,

Khedri,

Aminian

et al. 2023

Iran J Sci Technol Trans Mech Eng

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“…Theoretical studies have proven the efficiency of this novel magnetically targeted drug delivery system where the strong magnet can collect magnetic micro/nano-particles from arterial/ venous blood flow [2]. In the present paper, an in vitro flow model system was developed to validate the theoretical model and evaluate the efficiency of a bulk superconducting magnet to accumulate ferromagnetic particles (2 diameter) inside blood flow.…”

Section: Introductionmentioning

confidence: 98%

“…Indeed, we found that a magnetically assisted gene transfection system has considerable potential for a gene therapy [2]. Drug targeting is achieved Manuscript through venous injection of drug-loaded magnetic, biocompatible micro/nano-particles which freely circulate throughout the body but are magnetically trapped and concentrated at the local site under magnetic field (targeted delivery).…”

Section: Introductionmentioning

confidence: 99%

Three Dimensional Motion Control System of Ferromagnetic Particles for Magnetically Targeted Drug Delivery Systems

Mishima

Takeda

Izumi

et al. 2006

IEEE Trans. Appl. Supercond.

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The development of a 3-dimensional (3-D) navigation system of ferromagnetic particles in a flow system was performed. In order to improve the practice of using externally-applied magnetic fields for targeting the magnetic particles to a circumscribed body region, we tested the feasibility of a novel 3-D navigation system, made by applying a strong external (magnetic) field through a GdBaCuO bulk superconductor. A 3-D theoretical model is proposed and used in order to evaluate the efficiency of the navigation/retention of magnetic particles in the flow system. Furthermore, an experimental model system was made and the efficiency of a prototype system was examined. Comparisons of experimental and the corresponding calculation results were made to examine the theoretical model system.

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“…The importance of magnetic dipole interactions for targeting applications have been described previously [21][22][23]. Also there have been previous publications where a similar bifurcation has been modelled but in the context of permanent magnets and without cell aggregation [24,25]. However, in comparison to these studies we used cells with internalised particles and not magnetic particles alone.…”

Section: Effect Of Viscosity and Cell Concentrationmentioning

confidence: 99%

Magnetically assisted delivery of cells using a magnetic resonance imaging system

Riegler¹,

Allain²,

Cook³

et al. 2011

J. Phys. D: Appl. Phys.

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To cite this version:J Riegler, B Allain, R J Cook, M F Lythgoe, Q A Pankhurst. Magnetically assisted delivery of cells using a magnetic resonance imaging system. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (5) AbstractA simple analytical model is presented which enables rapid interactive prediction and control of magnetically labelled cells in an arterial bifurcation using magnetic field gradients produced by a magnetic resonance imaging system (MRI). This model is compared against experimental results for human mononuclear cells labelled with micron sized superparamagnetic iron oxide particles. Experimental and theoretical results highlight the importance of cell aggregation for magnetic targeting in a strong magnetic field. These predicted aggregates are confirmed via confocal endoscopy which allows the visualisation of cell aggregates and their movement inside a vascular flow model in a 9.4T preclinical MRI scanner.

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Development of magnetic force-assisted gene transfer system using biopolymer-coated ferromagnetic nanoparticles

Cited by 10 publications

References 7 publications

Effect of Particle–Particle and RBC–Particle Interactions on Capture Efficiency of Magnetic Nanocarriers Under the Influence of a Nonuniform Magnetic Field

Effect of Particle–Particle and RBC–Particle Interactions on Capture Efficiency of Magnetic Nanocarriers Under the Influence of a Nonuniform Magnetic Field

Three Dimensional Motion Control System of Ferromagnetic Particles for Magnetically Targeted Drug Delivery Systems

Magnetically assisted delivery of cells using a magnetic resonance imaging system

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