Development of Ly-1+ B cells in immunodeficient CBA/N mice.

Abstract

Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation antigen expression with the myelomonocytic lineage. Interestingly, expansion of formerly absent Ly-1+ B cells was paralleled by a severe reduction in common, Ly-1-, B cell development in the recipient. We conclude that precursors for Ly-1+ B lineage do exist in CBA/N mice.

Generation of Bone-Resorbing Osteoclasts from B220+ Cells: Its Role in Accelerated Osteoclastogenesis due to Estrogen Deficiency

“…The existence of bipotent B/macrophage cells has been reported (19) . B‐1 B cells express the macrophage marker CD11b, (25) and subclones of the 70Z/3 pre‐B cell line have been shown to develop into macrophage populations (18, 26) . Moreover, mouse strains carrying the IL‐7 trans ‐gene showed selective expansion of early stage B cells, which were phenotypically identical with bipotent B/macrophage cell populations (27) .…”

Expression of an immunoglobulin heavy chain transgene in macrophage as well as lymphocyte lineagesin vivo

“…(Fig. 3A and data not shown), likely to be peritoneal B-1 B cells known to express CD11b [34]. No F4/80 + cells in non-transgenic PRC stained positively for IgH ?…”

“…There are reports of connections between the macrophage and B cell lineages [37]: some B-1 B cells express the macrophage marker CD11b [34], some subclones of the 70Z/3 B lineage cell line develop into macrophage populations [38], and C ? transcripts have been reported in tumor cell lines of the monocytic lineage [39].…”