Development of luminescent nanoswitch for sensing of alkaline phosphatase in human serum based onAl3+-PPi interaction and Cu NCs with AIE properties

Geng, Fenghua; Zou, Changpeng; Liu, Jinhua; Zhang, Qianchen; Guo, Xueying; Fan, Yunchang; Yu, Hai‐Dong; Yang, Sheng; Liu, Zhipeng; Lin, Li

doi:10.1016/j.aca.2019.05.026

Cited by 31 publications

(8 citation statements)

References 55 publications

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“…The developed biosensor could operate in a wide linear range (0.5-25 mU/mL) with LOD of 0.15 mU/mL. 224 The opposite effect has been observed when poly(thymine)-CuNCs were applied for the detection of ALP. 262 In brief, the quenching of PL (in the presence of Cr 3+ ions) was restored by the addition of PPi, due to the strong binding affinity of pyrophosphate towards the chromium ions.…”

Section: Alkaline Phosphatase Activity Detectionmentioning

confidence: 99%

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Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

2021

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Section: Alkaline Phosphatase Activity Detectionmentioning

confidence: 99%

“…74 GSH-CuNCs with Al 3+ -triggered AIE enhancement were also applied for the ALP activity detection. 224 The addition of Al 3+ to the cluster solution caused aggregation and thus, PL enhancement. In the presence of PPi, due to the Al 3+ -PPi complexation, the Pl was quenched.…”

Section: Alkaline Phosphatase Activity Detectionmentioning

confidence: 99%

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

2021

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“…In addition, it was also reported that GSH-CuNCs exhibited a similar performance, which was used for detecting pyrophosphatase and alkaline phosphatase (Geng et al 2019;Ye et al 2019). The difference was that Fe 3+ was replaced by Al 3+ , which could enhance the fluorescence of GSH-CuNCs mainly due to the AIEE effect.…”

Section: Pyrophosphatase Detectionmentioning

confidence: 98%

Highly fluorescent copper nanoclusters for sensing and bioimaging

Ren

Bick

et al. 2020

Biosensors and Bioelectronics

137

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Metal nanoclusters (NCs), typically consisting of a few to tens of metal atoms, bridge the gap between organometallic compounds and crystalline metal nanoparticles. As their size approaches the Fermi wavelength of electrons, metal NCs exhibit discrete energy levels, which in turn results in the emergence of intriguing physical and chemical (or physicochemical) properties, especially strong fluorescence. In the past few decades, dramatic growth has been witnessed in the development of different types of noble metal NCs (mainly AuNCs and AgNCs). However, compared with noble metals, copper is a relatively earth-abundant and cost-effective metal. Theoretical and experimental studies have shown that copper NCs (CuNCs) possess unique catalytic and photoluminescent properties. In this context, CuNCs are emerging as a new class of nontoxic, economic, and effective phosphors and catalysts, drawing significant interest across the life and medical sciences. To highlight these achievements, this review begins by providing an overview of a multitude of factors that play central roles in the fluorescence of CuNCs. Additionally, a critical perspective of how the aggregation of CuNCs can efficiently improve the florescent stability, tunability, and intensity is also discussed. Following, we present representative applications of CuNCs in detection and bioimaging. Finally, we outline current challenges and our perspective on the development of CuNCs.When decreasing the size of nanoparticles so that it approaches the Fermi wavelength of an electron, novel optical, electrical and magnetic properties appear (Deng et al. 2018a; Li et al. 2016b;Moghadam and Rahaie 2019;Wang et al. 2018c). Commonly termed nanoclusters (NCs), these ultra-small nanoparticles, bridging the missing link between atoms and nanocrystals, have attracted considerable attention in both fundamental research and practical applications (Bagheri et al. 2017;Basu et al. 2019;Sun et al. 2019;Wang et al. 2016b). Benefiting from the great progress in nanosynthetic chemistry, high-quality Copper NCs (CuNCs) with tailored size and good stability can be easily obtained. CuNCs, therefore, constitute an active research direction due to their unique properties, such as high luminous efficiency, long fluorescence lifetime, good optical and chemical stability, and large stokes displacement, which distinguish them as a new type of fluorescent probe for optical sensing and bioimaging/labeling (Cao et al. 2014;Wang et al. 2017).In this review, we highlight recent developments of CuNCs, with a particular emphasis on the multiple factors affecting fluorescent properties of CuNCs, as well as the aggregation-induced emission enhancement (AIEE) effect. To appreciate these advances, applications focused on the detection of ions, macromolecules and bioimaging are summarized. Lastly, we will provide a brief conclusion, and will address future challenges in the rapidly growing field of fluorescent CuNCs. Multiple factors that govern the fluorescence of CuNCsDue to the size of CuNCs falls w...

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“…TA-Cu NCs were successfully shown to detect pyrophosphatase in human serum samples with a detection limit of 0.15 U/L. Moreover, glutathione-Cu NCs (GSH-Cu NCs) could exhibit an identical detection chemistry when the Fe 3+ was replaced by Al 3+ [ 102 , 103 ].…”

Section: Copper Nanoclusters (Cu Ncs) In Disease Diagnosis: Biosensor...mentioning

confidence: 99%

The Multifarious Applications of Copper Nanoclusters in Biosensing and Bioimaging and Their Translational Role in Early Disease Detection

et al. 2022

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Nanoclusters possess an ultrasmall size, amongst other favorable attributes, such as a high fluorescence and long-term colloidal stability, and consequently, they carry several advantages when applied in biological systems for use in diagnosis and therapy. Particularly, the early diagnosis of diseases may be facilitated by the right combination of bioimaging modalities and suitable probes. Amongst several metallic nanoclusters, copper nanoclusters (Cu NCs) present advantages over gold or silver NCs, owing to their several advantages, such as high yield, raw abundance, low cost, and presence as an important trace element in biological systems. Additionally, their usage in diagnostics and therapeutic modalities is emerging. As a result, the fluorescent properties of Cu NCs are exploited for use in optical imaging technology, which is the most commonly used research tool in the field of biomedicine. Optical imaging technology presents a myriad of advantages over other bioimaging technologies, which are discussed in this review, and has a promising future, particularly in early cancer diagnosis and imaging-guided treatment. Furthermore, we have consolidated, to the best of our knowledge, the recent trends and applications of copper nanoclusters (Cu NCs), a class of metal nanoclusters that have been gaining much traction as ideal bioimaging probes, in this review. The potential modes in which the Cu NCs are used for bioimaging purposes (e.g., as a fluorescence, magnetic resonance imaging (MRI), two-photon imaging probe) are firstly delineated, followed by their applications as biosensors and bioimaging probes, with a focus on disease detection.

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Development of luminescent nanoswitch for sensing of alkaline phosphatase in human serum based onAl3+-PPi interaction and Cu NCs with AIE properties

Cited by 31 publications

References 55 publications

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

Highly fluorescent copper nanoclusters for sensing and bioimaging

The Multifarious Applications of Copper Nanoclusters in Biosensing and Bioimaging and Their Translational Role in Early Disease Detection

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