Development of luminescent atacamite nanoclusters for bioimaging and photothermal applications

Abstract

Fluorescent atacamite nanoclusters (FANCs) have been developed and modified with silica for Drosophila salivary gland tissue imaging and photothermally induced cell death of osteosarcoma MG-63 cells. FANCs were synthesized with Moringa oleifera leaf extract without using any hazardous reducing and external capping agents. FANC was further used to evaluate light absorption, fluorescence emission, band gap, and magnetic properties as the first report on such nanoclusters. Upon excitation with a 350 nm light source, FANCs exhibited fluorescence at 460 nm, with a relative quantum yield of 0.3%. Besides, silica-encapsulated fluorescent atacamite nanoclusters (SEFANC) manifested remarkable improvement in emission, quantum yield (1.7%), shelf-life (15 d), biocompatibility, and photostability. Concomitantly, it has also increased the absorption in the near-infrared region and demonstrated high heat generation potential (42 • C → 50 • C). The above results suggest that FANC can be a potential candidate in the area of nanomedicine for a number of applications such as bioimaging, photothermal therapy, etc.

A simple, universal and multifunctional template agent for personalized treatment of bone tumors

“…There are a lot of studies based on PTT for tumor therapy [ 15 , 18 ]. As a mild, selective, effective and non-invasive approach, PTT can be used to chemotherapy-resistant OS with excellent outcomes, which has inspired increasing attention from researchers [ 19 ]. Though PTT is debatable for clinical application on bone tumor, it is getting more and more attention because of its efficient function in killing tumor cells.…”

White Light Emitting Gadolinium Oxide Nanoclusters for In‐vitro Bio‐imaging

“…Due to extended emission in the red spectrum by Gd 2 O 3 nanoclusters in the 400-800 nm region would allow easy penetration of red light radiating out of the deep tissue, resulting in higher signal to noise ratio (S/N). [18] However, investigation regarding the white light/RGB color emission from gadolinium oxides and its other polymorphs is minimal, but some recent works are being discussed here. In line with this, I Nelli et al synthesized the Lanthanide (Ln 3 +) doped white light emitting gadolinium dioxycarbonates, [19] F.Zaman et al synthesized the Dysprosium (Dy 3 + ) doped white light generating gadolinium borate glasses, [20] and Murat Erdemm et al formulated the Ytterbium/ Erbium (Yb 3 + /Er 3 + ) doped gadolinium gallium nanocrystal for white light emission.…”

“…Where broad white light spectrum would enable real‐time bioimaging in the red (R), green (G), and blue (B) region. Due to extended emission in the red spectrum by Gd 2 O 3 nanoclusters in the 400‐800 nm region would allow easy penetration of red light radiating out of the deep tissue, resulting in higher signal to noise ratio (S/N) [18] . However, investigation regarding the white light/RGB color emission from gadolinium oxides and its other polymorphs is minimal, but some recent works are being discussed here.…”