Development of &lt;sup&gt;99&lt;/sup&gt;Mo/&lt;sup&gt;99m&lt;/sup&gt;Tc Generator System for Production of Medical Radionuclide &lt;sup&gt;99m&lt;/sup&gt;Tc using a Neutron-activated &lt;sup&gt;99&lt;/sup&gt;Mo and Zirconium Based Material (ZBM) as its Adsorbent

Saptiama, Indra; Lestari, Enny; Sarmini, Endang; Lubis, Hotman; Marlina, M; Mutalib, Abdul

doi:10.17146/aij.2016.531

Cited by 17 publications

(12 citation statements)

References 8 publications

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“…The ZBM synthesis procedure was conducted by the modification procedure similar to PZC as described previously (I Saptiama et al 2016;Awaludin et al 2015). A zirconium (IV) chloride (ZrCl 4 ) was added to the mixture of THF and 2-propanol followed by another addition of water and THF.…”

Section: Methodsmentioning

confidence: 99%

“…A 99 Mo adsorption capacity and 99m Tc elution test of the selected ZBM variation were conducted by the procedure described by Saptiama et al (2016).…”

Section: Methodsmentioning

confidence: 99%

“…The 99 Mo/ 99m Tc generator based on non-fission 99 Mo which has a lower specific activity needs an adsorbent material which has a higher adsorption capacity than alumina. The Zirconium-Based Material (ZBM) which has a higher adsorption capacity to molybdenum is an alternative solution for development of 99 Mo/ 99m Tc generator based on non-fission 99 Mo (I Saptiama et al 2016;Munir et al 2017;Indra Saptiama et al 2014). The ZBM is an inorganic polymer of zirconium which contains chlorine on its surface and synthesized from zirconium chloride (ZrCl 4 ) as the main starting material.…”

Section: Development Of New Materials Formentioning

confidence: 99%

“…The ZBM has been developed by sol-gel process using tetraethyl ortho silicate (TEOS) coating to increase its hardness as well as using sodium hypochlorite to increase the 99m Tc yield (Awaludin et al 2015;Marlina et al 2016). The resulting 99m Tc had been tested for methylene diphosphonate (MDP) radiopharmaceuticals kit (I Saptiama et al 2016). Further development of the ZBM was carried out to increase the adsorption capacity to molybdenum and 99m Tc yield.…”

Section: Development Of New Materials Formentioning

confidence: 99%

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Influence Of Drying Time And Temperature On Zirconium-Based Material (ZBM) Properties For 99Mo/99mTc Generator Development

et al. 2018

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INFLUENCE OF DRYING TIME AND TEMPERATURE ON ZIRCONIUM-BASED MATERIAL (ZBM) PROPERTIES FOR 99Mo/99mTc GENERATOR DEVELOPMENT. Zirconium-based material (ZBM) has an important role in producing Technetium-99m (99m Tc) due to its high adsorption capacity to Molybdenum-99 (99 Mo). The adsorption capacity of the ZBM depends on the specific surface area which is influenced by several parameters in the synthesis process. This study aims to investigate the influence of drying time and temperature on the structure and specific surface area of the ZBM. Synthesis of the ZBM was carried out using zirconium chloride, 2-propanol, water and tetrahydrofuran at 75 °C, 90 °C and 120 °C and for 3 hr, 5 hr and 7 hr, respectively. Functional group and specific surface area of the ZBM was analyzed by FTIR and BET method, respectively. At the variation of drying time, the functional group pattern showed by FTIR spectra was not significantly different. The O-H group of the ZBM increased as the drying temperature decreases. At 75 and 90°C, the specific surface area increased as the function of time was increased but was decreased at 120°C. The highest surface area of the synthesized ZBM had a poor performance as a 99 Mo/ 99m Tc generator material, whereas the eluate met the required standard.

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Section: Methodsmentioning

confidence: 99%

“…A 99 Mo adsorption capacity and 99m Tc elution test of the selected ZBM variation were conducted by the procedure described by Saptiama et al (2016).…”

Section: Methodsmentioning

confidence: 99%

Section: Development Of New Materials Formentioning

confidence: 99%

Section: Development Of New Materials Formentioning

confidence: 99%

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Influence Of Drying Time And Temperature On Zirconium-Based Material (ZBM) Properties For 99Mo/99mTc Generator Development

et al. 2018

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“…Meanwhile, the Centre for Radioisotopes and Radiopharmaceutical Technology-National Nuclear Energy Agency (PTRR-BATAN) has also developed a zirconium-based material (ZBM) for use as 99 Mo adsorbent [6][7][8][9]. This material has been succesfully synthesized and used as 99 Tc generator.…”

mentioning

confidence: 99%

Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent

et al. 2018

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The fission-product 99 Mo, having a high specific activity, is commonly used in alumina-based 99 Mo /99m Tc generator. Due to the limitation on the use of fissionproduct 99 Mo, an alternative route for 99 Mo production, namely activation of natural molybdenum using thermal neutron, has been explored. Unfortunately, this neutronactivated 99 Mo has a low specific activity. Therefore, 99 Mo /99m Tc generator based on neutron-activated 99 Mo requires a column with higher capacity absorbent. Thus, in this study, the nanomaterial of alumina (nano--Al2O3) was synthesized which was expected to have a higher 99 Mo adsorption capacity, so that nano--Al2O3 could be potentially used as a matrix of column for 99 Mo/ 99m Tc generator based on neutron-activated 99 Mo. Nano--Al2O3 was synthesized by using sol-gel method and characterized using FTIR spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM). In addition, the Scherrer method was used to determine the size of the crystals. To determine the 99 Mo adsorption capacity of the synthesized nanoalumina, the nano--alumina was soaked in nitric acid solution for one hour at room temperature followed by removing the filtrate. Then, the nano--alumina was soaked in 99 Mo solution (Na2 99 MoO4) at certain conditions. The FTIR spectra for nano--alumina showed adsorption peak at 450-500 cm -1 which indicated the presence of Al-O bond. The XRD patterns of nanoalumina crystals showed peaks at 2θ region of 25.8°, 35.9°, 38°, 52.8°, and 57.7°, indicating that the synthesized alumina had an α-phase with an average crystal size of ~5.5 nm. The average 99 Mo adsorption capacity of the synthesized alumina was 47.55 ± 12.3 mg Mo/g nano--Al2O3.

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Development of mesoporous γ-alumina from aluminium foil waste for 99Mo/99mTc generator

Munir

Sriyono

Abidin

et al. 2020

J Radioanal Nucl Chem

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Development of <sup>99</sup>Mo/<sup>99m</sup>Tc Generator System for Production of Medical Radionuclide <sup>99m</sup>Tc using a Neutron-activated <sup>99</sup>Mo and Zirconium Based Material (ZBM) as its Adsorbent

Cited by 17 publications

References 8 publications

Influence Of Drying Time And Temperature On Zirconium-Based Material (ZBM) Properties For 99Mo/99mTc Generator Development

Influence Of Drying Time And Temperature On Zirconium-Based Material (ZBM) Properties For 99Mo/99mTc Generator Development

Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent

Development of mesoporous γ-alumina from aluminium foil waste for 99Mo/99mTc generator

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