Development of interferon alpha-2b microspheres with constant release

Improved Enzyme Activity and Stability in Polymer Microspheres by Encapsulation of Protein Nanospheres

“…The sustained delivery of proteins from bio-compatible polymers has attracted remarkable interest (1)(2)(3)(4). However, the necessary encapsulation of proteins in hydrophobic polymer microspheres remains challenging when using proteins in aqueous solutions (4).…”

Injectable long-acting systems for Radix Ophiopogonis polysaccharide based on mono-PEGylation and in situ formation of a PLGA depot

“…2 However, some time-drug plasma concentration profiles in published articles indicate an obvious burst release in the initial stages, while sustained but low steady plasma levels of drug have been observed at later stages. [16][17][18] In some cases, a small burst release is appropriate for the effect of the drug by rapidly reaching the effective drug concentration; however, an obvious burst release might trigger drug toxicity. Many approaches have been adopted to modulate drug release kinetics, among which a combination of different delivery systems is a simple one.…”

Critical attributes of formulation and of elaboration process of PLGA-protein microparticles

“…An interesting approach aimed to reduce the number of injections in these biological therapies consists of the microencapsulation of the proteins using biodegradable polymers (Andreas et al, 2011;Formiga et al, 2010;Li et al, 2011;Ma, 2014;Tran et al, 2012;Zhang et al, 2013). These microparticles allow a slow protein release, and more importantly, they provide protection for the proteins against proteases in the administration site (Han et al, 2014;Pisal et al, 2010;Yeh et al, 2007).…”