Development of Injectable Dosage Form of Phytodrug on the Basis of Hellellow, Yarrow, and Nettle for the Prevention and Treatment of Postpartum Diseases in Cows

Abstract

This paper discusses the prospect of developing an injectable form of herbal medicine as a uterotonic, antimicrobial, ruminatory, anti-inflammatory, hemostatic and immunostimulating agent, which includes alcohol tinctures of nettle, yarrow and hellebore, as well as propylene glycol. The methods of pharmaceutical analysis of medicinal plant raw materials, physicochemical and empirical methods were used to determine the optimal composition of the phytocomposition in the following ratio of components per 100 ml: hellebore tincture - 2.5 ml, yarrow tincture - 15.0 ml, nettle tincture - 15, 0 ml, propylene glycol - 67.5 ml. Phytopreparation is a transparent alcohol solution, dark green in color, without foreign impurities and sediment, with a specific smell, soluble in water and alcohol. The results of the safety assessment of the phytopreparation, carried out on laboratory animals, indicate its low toxicity in the enteral and parenteral routes of administration. In pilot studies conducted on cows with signs of acute catarrhal endometritis, which were injected intravenously with the test composition of the phytopreparation at a dose of 30 ml per head, positive results were obtained. 10-15 minutes after the intravenous administration of the phytopreparation in cows, a contraction of the muscles of the uterus and the release of exudate were recorded. The results of early gynecological medical examination of cows, carried out 14 days after calving, confirm the high therapeutic efficacy of the developed composition in acute purulent-catarrhal endometritis and subinvolution of the uterus in cows.