Development of immunization trials against Pasteurella multocida

Ahmad, Tarek A.; Rammah, Samar Saeed; Sheweita, Salah A.; Haroun, Medhat A.; El-Sayed, L.

doi:10.1016/j.vaccine.2013.11.068

Cited by 52 publications

(46 citation statements)

References 167 publications

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“…A variety of types of vaccine have been constructed to prevent pasteurellosis in livestock, but formulating effective vaccines is still a challenge (Ahmad et al, 2014). This study found respiratory niche association of some clonal isolates in rabbits, confirming the clonal nature and niche association of some P. multocida isolates in other previously reported animal hosts (Bisgaard et al, 2013;Davies et al, 2003Davies et al, , 2004Hotchkiss et al, 2011;Pors et al, 2011).…”

Section: Tablesupporting

confidence: 84%

“…multocida causes respiratory disease in all farm animals including poultry, cattle, sheep, goats, pigs, and rabbits (Boyce et al, 2010;Wilson and Ho, 2013;Ahmad et al, 2014). Clinical manifestations of these respiratory conditions range from asymptomatic or mild chronic upper respiratory inflammation to acute pneumonia or disseminated fatal disease (Wilson and Ho, 2013).…”

Section: Introductionmentioning

confidence: 99%

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An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association

García-Álvarez

Cháves

Fernández³

et al. 2015

Infection, Genetics and Evolution

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Section: Tablesupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association

García-Álvarez

Cháves

Fernández³

et al. 2015

Infection, Genetics and Evolution

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“…The maintenance of high individual levels of specific antibodies over several breeding seasons could strengthen herd immunity, but also allow the long-term transfer of potentially protective antibodies from breeding females to offspring via the egg yolk (Gasparini et al 2002;Garnier et al 2012). Vaccination against Pm is widely considered the most effective way to protect poultry flocks (Ahmad et al 2014) and autogenous vaccines are routinely used to reduce the risk of emergence of Pm and the mortality it causes (Christensen and Bisgaard 2000). On Amsterdam Island, vaccination has proven efficient to protect yellownosed albatross nestlings after direct vaccination , while non-vaccinated nestlings appear to die without mounting an immune response.…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Exposure of breeding albatrosses to the agent of avian cholera: dynamics of antibody levels and ecological implications

et al. 2019

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Despite critical implications for disease dynamics and surveillance in wild long-lived species, the immune response after exposure to potentially highly pathogenic bacterial disease agents is still poorly known. Among infectious diseases threatening wild populations, avian cholera, caused by the bacterium Pasteurella multocida, is a major concern. It frequently causes massive mortality events in wild populations, notably affecting nestlings of Indian yellow-nosed albatrosses (Thalassarche carteri) in the Indian Ocean. If adults are able to mount a long-term immune response, this could have important consequences regarding the dynamics of the pathogen in the local host community and the potential interest of vaccinating breeding females to transfer immunity to their offspring. By tracking the dynamics of antibodies against P. multocida during 4 years and implementing a vaccination experiment in a population of yellow-nosed albatrosses, we show that a significant proportion of adults were naturally exposed despite high annual survival for both vaccinated and non-vaccinated individuals. Adult-specific antibody levels were thus maintained long enough to inform about recent exposure. However, only low levels of maternal antibodies could be detected in nestlings the year following a vaccination of their mothers. A modification of the vaccine formulation and the possibility to re-vaccinate females 2 years after the first vaccination revealed that vaccines have the potential to elicit a stronger and more persistent response. Such results highlight the value of long-term observational and experimental studies of host exposure to infectious agents in the wild, where ecological and evolutionary processes are likely critical for driving disease dynamics.

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“…(23) Las vacunas anti P. multocida, pretenden disminuir la infección en animales ya que esta causa importantes pérdidas económicas a este nivel; sin embargo, esto podría eventualmente disminuir la infección en humanos ya que se disminuiría su reservorio más importante. (24) En Costa Rica no se conoce la prevalencia de P. multocida, sin embargo es muy importante obtener una historia bien detallada del contacto con animales en pacientes inmunocomprometidos, de la tercera edad, con enfermedades malignas, tratamiento inmunosupresor, trastornos hepáticos, tumores infiltrantes y patologías pulmonares en quienes se presente un cuadro clínico infeccioso sospechoso de infección por esta bacteria, que se reporta como causante de una mortalidad del 7% al 30% por bacteremia, sin foco de ingreso conocido.…”

Section: Discusión Y Análisis Del Casounclassified

Bacteremia primaria por Pasteurella multocida en un paciente con hepatopatía crónica y cáncer de pulmón

Valverde

Bogantes

Zúñiga³

2018

RC_UCR-HSJD

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Se presenta a continuación el caso de un paciente masculino de 47 años, con antecedente de hepatopatía crónica clasificada como Child Pugh B secundaria a infección por el virus de Hepatitis B, diabetes mellitus 2 e hipertensión arterial, quien consulta al servicio de emergencias por 5 meses de evolución de disnea en reposo, tos productiva y hemoptisis; habiéndose descartado tuberculosis se documenta con neumonía intersticial y bacteremia por Pasteurella multocida. En este mismo ingreso se diagnostica con cáncer de pulmón indiferenciado.

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Development of immunization trials against Pasteurella multocida

Cited by 52 publications

References 167 publications

An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association

An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association

Exposure of breeding albatrosses to the agent of avian cholera: dynamics of antibody levels and ecological implications

Bacteremia primaria por Pasteurella multocida en un paciente con hepatopatía crónica y cáncer de pulmón

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