An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association

García-Álvarez, Andrés; Cháves, Fernando; Fernández, A.; Sanz, Celia; Borobia, M.; Hierro, Eva

doi:10.1016/j.meegid.2015.07.018

Cited by 22 publications

(28 citation statements)

References 25 publications

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“…In consistent with the previous reports, the isolates of capsular type A (76.10%) or LPS genotype L3 (56.10%) were the most predominate strains [6,7,[11][12][13]. It was reported that P. multocida isolate of capsular type F was also detected in rabbits [6,7,13], and the strain was highly pathogenic for rabbits [14]. Further efforts are needed to confirm the epidemiology and pathogenicity of P. multocida strain of capsular type F in rabbits in Fujian Province.…”

Section: Discussionsupporting

confidence: 91%

“…In the PubMLST database (https://pubmlst.org/), strains belonged to the 3 STs were also found in rabbits from Spain, strains belonged to ST11 and ST12 were found in rabbits from Portugal, and strains belonged to ST12 were found in rabbits from China. Moreover, P. multocida strains belonged to other STs were also reported in rabbits in Italy and France [6,7]. The results suggested that the sequence types of P. multocida might different according to different regions.…”

Section: Discussionmentioning

confidence: 77%

“…However, subsequent reports showed that the toxA and tbpA genes were also detected in P. multocida strains from other hosts, suggesting that the toxA and tbpA genes might not host specific [5,18]. A previous report showed that the hgbB gene in the P. multocida strains of capsular type D belonged to ST11 was significantly associated with the respiratory disease in rabbits [6]. However, other studies showed that there were not relationships between hgbB gene and pasteurellosis in swine and sheep [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Rabbits are common hosts for P. multocida. The P. multocida infected rabbits are mainly characterized by rhinitis, tracheitis, pneumonia and otitis media [6][7][8]. To our knowledge, pasteurellosis was common and widespread in rabbits in Fujian Province, whereas the knowledge about the epidemiology and characterization of P. multocida was limited.…”

Section: Introductionmentioning

confidence: 90%

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Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China

Wang

Sang

Sun

et al. 2019

Preprint

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Background Pasteurella multocida is one of the important pathogens infects rabbits, causing major economic losses in commercial rabbit farming. In this study, 205 P. multocida isolates recovered from lungs of dead rabbits with respiratory disease were defined capsular serogroups, lipopolysaccharide (LPS) genotypes and multi-locus sequence types, screened virulence factors, and tested antimicrobial susceptibility. Results The 205 isolates were assigned into 2 capsular types, A and D, and 2 LPS genotypes, L3 and L6. When combining capsular types with LPS genotypes, 4 serotypes were detected. A:L3 (51.22%, 105/205) was the most predominant serotype, followed by A:L6 (24.88%, 51/205), D:L6 (19.02%, 39/205), and D:L3 (4.88%, 10/205). The 205 isolates were grouped into 3 sequence types, ST10, ST11 and ST12. ST12 (56.10%, 115/205) was the most prevalent sequence type, followed by ST10 (24.88%, 51/205) and ST11 (19.02%, 39/205). In the 205 isolates, the virulence genes of ptfA, fur, hgbB, ompA, ompH and oma87 were positive, whereas the toxA and tbpA genes were negative. Notably, the 156 capsular serogroup A isolates carried pmHAS gene. All the 205 isolates were susceptible to most of the used antibiotics, except for streptomycin, gentamycin, kanamycin and ceftriaxone, and the resistance rates of which were 27.80%, 15.61%, 9.27% and 2.44%, respectively. Conclusions This study, for the first time, described the prevalence and characteristics of P. multocida causing respiratory disease in rabbits in Fujian Province, which might be useful for tracking the epidemic strains and development of efficient vaccines and methods to prevent and control the pathogen.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China

Wang

Sang

Sun

et al. 2019

Preprint

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“…The 205 P. multocida isolates in this study were grouped into 4 serotypes of A:L6, A:L3, D:L6 and D:L3. In consistence with the previous reports, the isolates of capsular type A (76.10%) or LPS genotype L3 (56.10%) were the most predominate strains [6][7][8][9][10]. However, the highly pathogenic strain of capsular type F was not detected in this study [6,7,10,13].…”

Section: P Multocida Strains Were Classified Into 5 Capsular Types (supporting

confidence: 86%

Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China

Wang¹,

Sang

Sun

et al. 2019

Preprint

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Background: Pasteurella multocida is one of the important pathogens that infect rabbits, causing major economic losses in commercial rabbit farming. In this study, 205 P. multocida isolates recovered from lungs of dead rabbits with respiratory disease were defined by capsular serogroups, lipopolysaccharide (LPS) genotypes, multi-locus sequence types and screened virulence factors by using PCR assays, and tested antimicrobial susceptibility. Results: The 205 isolates were assigned into 2 capsular types, A and D, and 2 LPS genotypes, L3 and L6. When combining capsular types with LPS genotypes, 4 serotypes were detected. A:L3 (51.22%, 105/205) was the most predominant serotype, followed by A:L6 (24.88%, 51/205), D:L6 (19.02%, 39/205) and D:L3 (4.88%, 10/205). The 205 isolates were grouped into 3 sequence types, ST10, ST11 and ST12. ST12 (56.10%, 115/205) was the most prevalent sequence type, followed by ST10 (24.88%, 51/205) and ST11 (19.02%, 39/205). In the 205 isolates, virulence associated genes ptfA, fur, hgbB, ompA, ompH and oma87 were positive in the PCR screening, whereas the toxA and tbpA genes were negative. Notably, the 156 capsular serogroup A isolates carried the pmHAS gene. All the 205 isolates were susceptible to most of the used antibiotics, except for streptomycin, gentamycin, kanamycin and ceftriaxone, and the resistance rates of which were 27.80%, 15.61%, 9.27% and 2.44%, respectively. Conclusions: This study, for the first time, described the prevalence and characteristics of P. multocida causing respiratory disease in rabbits in Fujian Province, which might be useful for tracking the epidemic strains and development of efficient vaccines and methods to prevent and control the pathogen.

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Respiratory Complex in Rabbits (Pasteurellosis)

Simões,

Saraiva,

da Conceição Medeiros Castro Fontes

et al. 2024

Veterinary Care of Farm Rabbits

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An ST11 clone of Pasteurella multocida, widely spread among farmed rabbits in the Iberian Peninsula, demonstrates respiratory niche association

Cited by 22 publications

References 25 publications

Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China

Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China

Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China

Respiratory Complex in Rabbits (Pasteurellosis)

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