Development of Hypertension and Cardiovascular-Renal Lesions During Adrenal Regeneration in the Rat.

Skelton, Floyd R.

doi:10.3181/00379727-90-22028

Cited by 89 publications

(22 citation statements)

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“…This fact is of interest in connexion with the pathogenesis of the hypertension which develops if one adrenal is removed and the other enucleated (the precise conditions used in our experiments) in rats sensitized by unilateral nephrectomy and a high sodium intake (Skelton, 1955(Skelton, , 1956Skelton & Guillebeau, 1956;Chart, Ulsamer, Quinn, Howie, Sullivan & Gaunt, 1957). It is evident from our results that an increased secretion of aldosterone, suggested by Skelton & Guillebeau (1956) must be ruled out as a cause of the hypertension observed in such experimental conditions.…”

Section: Secretion Of Regenerating Adrenalsmentioning

confidence: 95%

The secretion of corticosterone and aldosterone by the rat adrenal cortex regenerating after enucleation

Brogi¹,

Pellegrino²

1959

The Journal of Physiology

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The rat and mouse adrenal gland shows a notable regenerative capacity after enucleation. By this operation the whole medulla and the greater part of the cortex are removed, except for some cells of the zona glomerulosa adhering to the capsule (Evans, 1936;Greep & Deane, 1949;Pellegrino, 1951b). These cells, by hypertrophy and hyperplasia, give rise to a new cortex.From the point of view of the functions of the gland, the animals with enucleated adrenals are very similar, for a short time after the operation, to adrenalectomized ones. During the course of the regeneration many of the disturbances induced by the operation subside, mainly within the first month. A period which extends approximately from the 5th to the 15th day after the enucleation is marked by the re-establishment of normal body weight, lost during fasting (Pellegrino, 1951a) and by the recovery of fat (Hartman, Brownell & Knouff, 1947), carbohydrate (Brownell & Hartman, 1948; Pellegrino, 1952; WPellegrino & Caramazza, 1955) and protein metabolism (Pellegrino, 1952;Torcigliani, 1955). During the second half of the first month after enucleation, restoration of the cortical control over lymphatic tissue (Pellegrino, 1950) was observed.In connexion with this work it was considered interesting to investigate by direct methods the secretory ability of the regenerating adrenal, by analyses of steroids in the venous effluent from the gland. This study might also offer data bearing on the question of the secretion of specific hormones by given zones of the cortex (Greep & Deane, 1947). In fact, in the first stages of regeneration after enucleation the newly formed cells are disposed in columns and no glomerulosa or reticularis are detectable. The zona glomerulosa is clearly differentiated about a fortnight after enucleation and the zona reticularis still later. It was therefore decided that besides corticosterone (the main steroid secreted by the rat adrenal (Bush, 1953)) aldosterone secretion should also be

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Section: Secretion Of Regenerating Adrenalsmentioning

confidence: 95%

The secretion of corticosterone and aldosterone by the rat adrenal cortex regenerating after enucleation

Brogi¹,

Pellegrino²

1959

The Journal of Physiology

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“…Experimental hypertension in rats associated with adrenal cortical regeneration Skelton has recently demonstrated a form of experimental hypertension in rats which appears during the regeneration of adrenal cortical tissue following adrenal enucleation (13). In creating this experimental situation, we removed one kidney and one adrenal in male weanling Holtzmann rats.…”

Section: B Adrenal Insufficiencymentioning

confidence: 99%

The Granulation of Juxtaglomerular Cells in Renal Hypertension, Desoxycorticosterone and Post-Desoxycorticosterone Hypertension, Adrenal Regeneration Hypertension, and Adrenal Insufficiency12

Tobian¹,

Thompson²,

Twedt³

et al. 1958

J. Clin. Invest.

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“…Many studies have been made of the pathological changes in the blood vessels in human and experimental hypertension both by light [12,15,26,27,30,32,37] and electron microscopy [13,18,23,28,32,34], The rat has dominated the literature as an experimental animal. The in vestigation of hypertensive states, both spontaneous and those induced by renal abnormalities, steroid and salt treatment, adrenal regeneration, aortic stenosis, and drugs, in this species has furnished data elucidating mechanisms of this disease.…”

Section: Introductionmentioning

confidence: 99%

An Autoradiographic and Pathological Study of Cellular Proliferation in Rabbit Arteries Correlated with an Increase in Arterial Pressure

Bevan¹

1976

J Vasc Res

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Following partial constriction of the abdominal aorta, the increase in arterial pressure in vessels proximal to the ligature at 3, 6, 14, 21 and 28 days was correlated with pathological changes and with proliferation of cells in the arterial wall measured by ³H-thymidine labeling indices and mitotic counts. The time course of arterial pressure rise and vascular smooth muscle cell proliferation were similar. Patterns of proliferation of cells of the artery wall varied in distribution with time, the presence or absence of traumatic changes seen by light microscopy, and the histological structure of the vessel. Arteries not subject to hypertension did not differ from sham-operated animals.

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Development of Hypertension and Cardiovascular-Renal Lesions During Adrenal Regeneration in the Rat.

Cited by 89 publications

References 0 publications

The secretion of corticosterone and aldosterone by the rat adrenal cortex regenerating after enucleation

The secretion of corticosterone and aldosterone by the rat adrenal cortex regenerating after enucleation

The Granulation of Juxtaglomerular Cells in Renal Hypertension, Desoxycorticosterone and Post-Desoxycorticosterone Hypertension, Adrenal Regeneration Hypertension, and Adrenal Insufficiency12

An Autoradiographic and Pathological Study of Cellular Proliferation in Rabbit Arteries Correlated with an Increase in Arterial Pressure

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