Development of Hyperalgesia in Patients Treated with Autologous Platelet Rich Plasma Due to Androgenetic Alopecia

Systematic review: The platelet-rich plasma use in female androgenetic alopecia as effective autologous treatment of regenerative plastic surgery

“…During a deeper analysis of the literature, on the potential side effects of PRP treatment, two works 25 , 26 reported hyperalgesia after PRP injections. Yildirim et al 25 reported hyperalgesia in patients treated with repeated PRP injections. The development of hyperalgesia in these patients may be due to the growth factors contained in PRP, but further experimental and clinical studies are needed to determine the effective cause of hyperalgesia occurring after repeated PRP injections.…”

Transitory hair growth using platelet‐rich plasma therapy in stabilized central centrifugal cicatricial alopecia

“…This differs from hyperalgesia reported in patients treated with PRP for androgenetic alopecia. 8 Because of their CCCA, both received intralesional corticosteroids in the past, making them possibly more used to intralesional therapies. We are the first to report a persistently decreased hair density under the 6‐month interval maintenance sessions.…”

The effects of a combination treatment with mesenchymal stem cell and platelet rich plasma on tendon healing: an experimental study

“…It has been reported that growth factors that are considered to affect the healing process might, because of their effects in increasing tendon regeneration, be able to be used in the treatment by giving direct local injections to the lesion sites (8). There are studies in the literature that show the positive effects that PRP and mesenchymal stem cell injections have on tendon healing (9). However, there have been no controlled experimental studies that have demonstrated and compared these effects (10).…”