Systematic review: The platelet-rich plasma use in female androgenetic alopecia as effective autologous treatment of regenerative plastic surgery

Gentile, Pietro; Garcovich, Simone

doi:10.1016/j.bjps.2021.11.004

Cited by 11 publications

(14 citation statements)

References 25 publications

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“…Adding PRP to Hyaluronic Acid dressing has been shown to accelerate the healing process in surgical, post‐traumatic, and chronic wounds (Cervelli et al., 2011; De Angelis et al., 2019; Nicoli et al., 2015). Moreover, promising results were obtained in treating pattern alopecia with PRP alone or combined with other methods such as human follicle mesenchymal stem cell micro‐grafting (Gentile et al., 2015; Gentile and Garcovich, 2020, 2021b; Giordano et al., 2017). It is worth mentioning that PRP, in conjunction with autologous fat, has shown promising results also in the management of more severe forms of scars with more prominent loss of subcutaneous tissue such as post‐traumatic or burn scars, hemifacial atrophy, tissue loss due to aging, etc.…”

Section: Discussionmentioning

confidence: 99%

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Ebrahimi

Alimohamadi

Janani

et al. 2022

J Tissue Eng Regen Med

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Despite the rising trend for applying platelet‐rich plasma (PRP) in the management of various types of scars, there is no convincing evidence supporting its use. This motivated us to review the randomized clinical trials that examine the effectiveness and safety of PRP, alone or in combination with other methods, for the management of atrophic or hypertrophic/keloidal scars. The Web of Science, Scopus, Google Scholar, and Cochrane Library databases were systematically searched until September 1st, 2020. Thirteen clinical trials were enrolled in the meta‐analysis, and 10 more were reviewed for their results. The random effect meta‐analysis method was used to assess the effect size of each outcome for each treatment type, and I2 was used to calculate the statistical heterogeneity between the studies. Patients treated with PRP experienced an overall response rate of 23%, comparable to the results seen with laser or micro‐needling (22% and 23%, respectively) When used alone, moderate improvement was the most frequently observed degree of response with PRP (36%) whereas, when added to laser or micro‐needling, most patients experienced marked (33%, 43%, respectively) or excellent (32% and 23%, respectively) results. Concerning the hypertrophic/keloid scars, the only study meeting the required criteria reported a better improvement and fewer adverse effects when PRP was added to the intralesional corticosteroids. Platelet‐rich plasma appears to be a safe and effective treatment for various types of atrophic scars. In addition, when added to ablative lasers or micro‐needling, it seems to considerably add to the efficacy of treatment and reduce the side effects.

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Section: Discussionmentioning

confidence: 99%

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Ebrahimi

Alimohamadi

Janani

et al. 2022

J Tissue Eng Regen Med

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“…In addition to its effects on chronic wounds and vitiligo, PRP has also shown promising results in hair regrowth, female alopecia, and bone tissue defects 61–64 . A randomized placebo‐controlled trial by Gentile et al 61 .…”

Section: Discussionmentioning

confidence: 99%

The use of platelet‐rich plasma in wound healing and vitiligo: A systematic review and meta‐analysis

Wang,

Feng,

Chang

et al. 2023

Skin Research and Technology

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ObjectiveTo critically assess the effect and safety of platelet‐rich plasma (PRP) in chronic wounds and vitiligo.MethodsA systematic literature searching was performed. Results were expressed as weight mean difference (WMD) or risk ratio (RR) with 95% confidence intervals (CIs). Pooled estimates were performed using a fixed‐effects model or random‐effects model, depending on the heterogeneity among studies.ResultsA total of 27 studies were included in this meta‐analysis. In patients with chronic diabetic ulcers, PRP significantly increased proportion of complete wound healing, percentage of wound area healed, and shortened the complete wound healing. In venous ulcers, PRP improved the epithelialized area and percentage of wound area healed. In vitiligo, PRP had better results in degree of improvement and mean repigmentation than controls. Regarding the safety profile, PRP did not increase the risk of infection in patients with chronic diabetic ulcers. Meta‐regression revealed that source of PRP and preparation method of PRP significantly affected the proportion of complete wound healing, whereas age, gender, country, duration of wound, and wound size had no impact on this outcome.ConclusionPRP is effective and safe, and can be used as a potential therapeutic adjunct or alternative treatment in chronic wounds of multiple etiologies and vitiligo.

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“…In some studies, PRP was used for post-extraction sockets and bone regeneration after teeth extraction with significant improvement [ 81 , 82 ]. Additionally, more than three injections of the autologous non-activated platelet-rich plasma (A-PRP) and calcium-activated platelet-rich plasma (AA-PRP) into scalps increased the activation of Bcl-2 protein (anti-apoptotic regulator), CD31 (Platelet endothelial cell adhesion molecule-1), VEGF and Akt signaling pathways, leading to improving the dermal papilla cells survival and proliferation during the hair cycle, and ultimately to improved hair count and density in both male and female patients with androgenetic alopecia [ 77 , 78 , 79 , 83 , 84 , 85 , 86 , 87 ].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model

Chueh

Huang

et al. 2022

IJMS

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The present study attempted to elucidate whether intravesical instillation of platelet-rich plasma (PRP) could decrease bladder inflammation and ameliorate bladder hyperactivity in ketamine ulcerative cystitis (KIC) rat model. Female Sprague Dawley (S-D) rats were randomly divided into control group, ketamine-treated group, ketamine with PRP treated group, and ketamine with platelet-poor plasma (PPP) treated group. Cystometry and micturition frequency/volume studies were performed to investigate bladder function. The morphological change of bladder was investigated by Mason’s trichrome staining. Western blotting analysis were carried out to examine the protein expressions of inflammation, urothelial differentiation, proliferation, urothelial barrier function, angiogenesis and neurogenesis related proteins. The results revealed that treatment with ketamine significantly deteriorated bladder capacity, decreased voiding function and enhanced bladder overactivity. These pathological damage and interstitial fibrosis may via NF-κB/COX-2 signaling pathways and muscarinic receptor overexpression. PRP treatment decreased inflammatory fibrotic biosynthesis, attenuated oxidative stress, promoted urothelial cell regeneration, and enhanced angiogenesis and neurogenesis, thereafter recovered bladder dysfunction and ameliorate the bladder hyperactivity in KIC rat model. These findings suggested that the PRP therapy may offer new treatment options for those clinical KIC patients.

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Systematic review: The platelet-rich plasma use in female androgenetic alopecia as effective autologous treatment of regenerative plastic surgery

Cited by 11 publications

References 25 publications

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

Platelet‐rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta‐analysis

The use of platelet‐rich plasma in wound healing and vitiligo: A systematic review and meta‐analysis

Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model

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