Development of hydroxyapatite derived from Indian coral

Sivakumar, M.; Kumar, T.S. Sampath; Shantha, K. L.; Rao, K. Panduranga

doi:10.1016/0142-9612(96)87651-4

Cited by 218 publications

(122 citation statements)

References 12 publications

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“…HAp can act as a reticular modifier agent (due to the presence of calcium and phosphorous) and its use as bone former (Felício-Fernandes and Laranjeira 2000), has also been appraised. Its superior osteoconductive properties render HAp a vast potential to be used in implants as bone substitute (Sivakumar et al 1996).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration

Finisie

Josué

Fávere

et al. 2001

An. Acad. Bras. Ciênc.

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Bioceramic composites were obtained from chitosan and hydroxyapatite pastes synthesized at physiological temperature according to two different syntheses approaches. Usual analytical techniques (X-ray diffraction analysis, Fourier transformed infrared spectroscopy, Thermo gravimetric analysis, Scanning electron microscopy, X-ray dispersive energy analysis and Porosimetry) were employed to characterize the resulting material. The aim of this investigation was to study the bioceramic properties of the pastes with nondecaying behavior from chitosan-hydroxyapatite composites. Chitosan, which also forms a water-insoluble gel in the presence of calcium ions, and has been reported to have pharmacologically beneficial effects on osteoconductivity, was added to the solid phase of the hydroxyapatite powder. The properties exhibited by the chitosan-hydroxyapatite composites were characteristic of bioceramics applied as bone substitutes. Hydroxyapatite contents ranging from 85 to 98% (w/w) resulted in suitable bioceramic composites for bone regeneration, since they showed a non-decaying behavior, good mechanical properties and suitable pore sizes.

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Section: Introductionmentioning

confidence: 99%

“…Calcium phosphate based bioceramics have recently received special attention as bone replacement materials, as they behave similarly to the mineral constituent of bones (Martin and Brown 1995, Felício-Fernandes and Laranjeira 2000, Pereira et al 1999, Kawachi et al 2000, Shareef et al 1993, Sivakumar et al 1996.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration

Finisie

Josué

Fávere

et al. 2001

An. Acad. Bras. Ciênc.

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“…Investigation of hydroxyl and carbonate groups in the obtained apatites was achieved by IR spectroscopy and thermal gravimetric analysis (TGA). IR spectroscopy is a powerful method in ionic investigation and has been used extensively in phosphate minerals research [37][38][39]. Transmission Electron microscopy (TEM), electron scanning microscopy (SEM), energy dispersive X-ray analysis (EDX) and field emission scanning electron microscopy (FE SEM) were also utilized in the physiochemical characterization process for the obtained materials.…”

Section: Introductionmentioning

confidence: 99%

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Barakat

Khalil

Sheikh

et al. 2008

Materials Science and Engineering: C

168

109

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“…Moreover, several studies reported that biocompatible HAp can be successfully fabricated from natural products via hydrothermal reactions. 7 As an example, coral exoskeleton is composed mainly of a calcium carbonate phase on an organized organic template and is used after transformation into HAp. 7 Because of its good mechanical properties and porous structure, 8 it is a good candidate as a bone regenerative substitute and scaffold.…”

Section: Introductionmentioning

confidence: 99%

“…7 As an example, coral exoskeleton is composed mainly of a calcium carbonate phase on an organized organic template and is used after transformation into HAp. 7 Because of its good mechanical properties and porous structure, 8 it is a good candidate as a bone regenerative substitute and scaffold. In naturally derived biomaterials, cuttlefish bones (CB) have a similar chemistry and crystallography as coral 9 ; they are also low cost and readily available.…”

Section: Introductionmentioning

confidence: 99%

Improvement of the compressive strength of a cuttlefish bone‐derived porous hydroxyapatite scaffold via polycaprolactone coating

Kim

Kang

Liu

2013

J. Biomed. Mater. Res.

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Cuttlefish bones (CBs) have emerged as attractive biomaterials because of their porous structure and components that can be converted into hydroxyapatite (HAp) via a hydrothermal reaction. However, their brittleness and low strength restrict their application in bone tissue engineering. Therefore, to improve the compressive strength of the scaffold following hydrothermal conversion to a HAp form of CB (CB-HAp), the scaffold was coated using a polycaprolactone (PCL) polymer at various concentrations. In this study, raw CB was successfully converted into HAp via a hydrothermal reaction. We then evaluated their surface properties and composition by scanning electron microscopy and X-ray diffraction analysis. The CB-HAp coated with PCL showed improved compressive performance and retained a microporous structure. The compressive strength was significantly increased upon coating with 5 and 10% PCL, by 2.09-and 3.30-fold, respectively, as compared with uncoated CB-HAp. However, coating with 10% PCL resulted in a reduction in porosity. Furthermore, an in vitro biological evaluation demonstrated that MG-63 cells adhered well, proliferated and were able to be differentiated on the PCL-coated CB-HAp scaffold, which was noncytotoxic. These results suggest that a simple coating method is useful to improve the compressive strength of CB-HAp for bone tissue engineering applications.

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Development of hydroxyapatite derived from Indian coral

Cited by 218 publications

References 12 publications

Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration

Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Improvement of the compressive strength of a cuttlefish bone‐derived porous hydroxyapatite scaffold via polycaprolactone coating

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