1989
DOI: 10.1111/1523-1747.ep12580896
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Development of Human Embryonic and Fetal Dermal Vasculature.

Abstract: This report summarizes recent advances in the understanding of the structure and organization of the microvasculature in developing human skin. Previous observations suggested that the skin contains no blood vessels as late as eight weeks estimated gestational age (EGA). Computer reconstructions, in conjunction with light and transmission electron microscopy (TEM), however, demonstrated that specimens as young as 35-45 d show a level of vascular complexity previously unknown. The computer reconstructions showe… Show more

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Cited by 17 publications
(3 citation statements)
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“…Given the important functional basis for the organisation of the dermal vasculature, it is likely that cues from the vasculature help to establish the architecture of the epidermal-dermal interface. The pattern of dermal capillaries emerges early during embryogenesis coincident with the development of the epidermis [ 35 , 36 , 37 ]. By birth, the skin possesses a mature capillary architecture; however, little is known about the mechanisms by which the epidermis organises around the capillaries to achieve this state.…”
Section: Rete Ridges and Capillariesmentioning
confidence: 99%
“…Given the important functional basis for the organisation of the dermal vasculature, it is likely that cues from the vasculature help to establish the architecture of the epidermal-dermal interface. The pattern of dermal capillaries emerges early during embryogenesis coincident with the development of the epidermis [ 35 , 36 , 37 ]. By birth, the skin possesses a mature capillary architecture; however, little is known about the mechanisms by which the epidermis organises around the capillaries to achieve this state.…”
Section: Rete Ridges and Capillariesmentioning
confidence: 99%
“…The vertebrate skin undergoes dramatic changes as animals develop from embryonic to adult stages. The epidermis grows from a simple mono- or bilayered epithelium to a stratified multi-layer epithelium, dermal vasculature elaborates, specialized sensory structures and dermal appendages appear, and the skin area greatly expands (Jenkins and Lumpkin, 2017; Johnson and Holbrook, 1989; Munger and Ide, 1988). How these events are coordinated, and how nerves and blood vessels remodel to accommodate these dramatic changes in the skin, has not been well characterized.…”
Section: Introductionmentioning
confidence: 99%
“…ECM is known to promote development and angiogenesis in kidney organoids that mimic embryonic organs 27). Additionally, some components of ECM have been reported to play a role in directing the migration of endothelial cells, contributing to angiogenesis 28). Thus, an analysis focusing on the unique ECM composition of the fetal subcutaneous space is necessary in the future to understand the difference between adult and fetal subcutaneous transplantation.…”
Section: Discussionmentioning
confidence: 99%