Development of Houttuynia cordata Extract-Loaded Solid Lipid Nanoparticles for Oral Delivery: High Drug Loading Efficiency and Controlled Release

Abstract

Houttuynia cordata (H. cordata) has been used for diuresis and detoxification in folk medicine as well as a herbal medicine with antiviral and antibacterial activities. H. cordata extract-loaded solid lipid nanoparticles (H-SLNs) were prepared with various concentration of poloxamer 188 or poloxamer 407 by a hot homogenization and ultrasonication method. H-SLNs dispersion was freeze-dried with or without trehalose as a cryoprotectant. The physicochemical characteristics of H-SLNs were evaluated by dynamic laser scattering (DLS), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Additionally, the in vitro release and in vitro cytotoxicity of H-SLNs were measured. Encapsulation efficiencies of H-SLNs (as quercitrin) were 92.9–95.9%. The SEM images of H-SLNs showed that H-SLNs have a spherical morphology. DSC and FT-IR showed that there were no interactions between ingredients. The increased extent of particle size of freeze-dried H-SLNs with trehalose was significantly lower than that of H-SLNs without trehalose. H-SLNs provided sustained release of quercitrin from H. cordata extracts. Cell viability of Caco-2 cells was over 70% according to the concentration of various formulation. Therefore, it was suggested that SLNs could be good carrier for administering H. cordata extracts.

Chinese White Wax Solid Lipid Nanoparticles as a Novel Nanocarrier of Curcumin for Inhibiting the Formation of Staphylococcus aureus Biofilms

“…In this work, SLNs were prepared with Chinese white wax for the first time by using the high shear homogenization and ultrasound method [20,21]. Meanwhile, the conditions for preparing the SLNs were also optimized.…”

<p>Solutol^®HS15+pluronicF127 and Solutol^®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein</p>

“…Therefore, improving the oral bioavailability of drugs is vital but is limited by their formulation. Currently, oral absorption technology of poorly soluble drugs has been reported in numerous studies, including those that employ solid dispersions,14,15 liposomes,16–19 micelles,20–24 and nanoparticles 25–29. Among these, mixed micelles have attracted much attention as a nano-sized drug carrier in DDSs.…”

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

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