Chinese White Wax Solid Lipid Nanoparticles as a Novel Nanocarrier of Curcumin for Inhibiting the Formation of Staphylococcus aureus Biofilms

Luan, Lin; Chi, Zhe; ChenGuang, Liu

doi:10.3390/nano9050763

Cited by 23 publications

(15 citation statements)

References 44 publications

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“…Furthermore, the microemulsion process is a less industry-amenable method. Similarly, a high entrapment efficiency of 84.6% is also reported elsewhere [ 31 ], but again at a much lower drug payload of 6.6% to 10% and employing high shear homogenization followed by ultrasonication. The particle size of the SLNs prepared by these workers was 401.9 nm.…”

Section: Resultssupporting

confidence: 78%

“…The latter is especially useful in the wound healing process. Several attempts have been made to prepare nanoparticles of curcumin, but the reported drug payload with respect to lipids is usually ≤10% w / w [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Similarly, the drug content of most of the reported SLN formulations is less than 5 mg/mL [ 34 , 35 , 36 , 37 , 38 , 39 ] and also involves the use of harmful organic solvents for their preparation and development [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

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Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

et al. 2021

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The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid lipid nanoparticles (CSLNs) for wound healing. CSLNs prepared by hot, high-pressure homogenization, without using organic solvents, were optimized using the Taguchi design followed by the central composite design. The optimized CSLNs exhibited a high assay/drug content (0.6% w/w), solubility (6 × 105 times), and EE (75%) with a particle size < 200 nm (PDI—0.143). The CSLNs were safe (in vitro and in vivo), photostable, autoclavable, stable up to one year at 30 °C and under refrigeration and exhibited a controlled release (zero-order; 5 days). XRD, FTIR, and DSC confirmed solubilization and entrapment of the curcumin within the SLNs. TEM and FESEM revealed a smooth and spherical shape. The CSLNs showed a significant antimicrobial effect (MIC of 64 µg/mL for planktonic cells; 512 µg/mL for biofilm formation; and 2 mg/mL for mature biofilm) against Staphylococcus aureus 9144, while free curcumin dispersion did not exhibit any effect. This is the first report on the disruption of mature biofilms by curcumin solid lipid nanoparticles (CSLNs). The cell proliferation potential of CSLNs was also evaluated in vitro while the wound healing potential of CSLNs (incorporated in a hydrogel) was assessed in vivo. In (i) nitrogen mustard gas and (ii) a full-thickness excision wound model, CSLNs exhibited (a) significantly faster wound closure, (b) histologically and immunohistochemically better healing, (c) lower oxidative stress (LPO) and (d) inflammation (TNFα), and (e) increased angiogenesis (VEGF) and antioxidant enzymes, i.e., catalase and GSH levels. CSLNs thus offer a promising modern wound therapy especially for infected wounds, considering their effects in mature biofilm disruption.

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Section: Resultssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

et al. 2021

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“…In the same line, a recent work described the load of SLN with curcumin, using high‐pressure homogenization, combined with a high‐shear dispersion method, and it was found that curcumin chemical stability and dispersibility in aqueous medium ameliorated, as well as the pharmacokinetic profiles in rats (administered by jugular vein cannulation) (Sun et al, 2013). More recently, SLN coupled with white wax and loaded with curcumin, resulted in a sustained drug release and blockage of Staphylococcus aureus growth (Luan, Chi, & Liu, 2019). In addition, these nanoformulations have also shown good safety profiles in both animals and humans, but further investigations are needed, especially in case of multiple administrations or for prolonged treatments.…”

Section: Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half‐life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

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“…As reported earlier, curcumin has been extensively studied for cancer. Curcumin is a natural polyphenolic compound extracted from the rhizomes of Curcuma longa and shows different biological activities in an antioxidant and anti-inflammatory capacity, among others [124]. To date, no clinical trial aimed directly to cancer therapy has been undertaken.…”

Section: Nanoemulsions Applied To Cancer Therapymentioning

confidence: 99%

Current Applications of Nanoemulsions in Cancer Therapeutics

et al. 2019

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Nanoemulsions are pharmaceutical formulations composed of particles within a nanometer range. They possess the capacity to encapsulate drugs that are poorly water soluble due to their hydrophobic core nature. Additionally, they are also composed of safe gradient excipients, which makes them a stable and safe option to deliver drugs. Cancer therapy has been an issue for several decades. Drugs developed to treat this disease are not always successful or end up failing, mainly due to low solubility, multidrug resistance (MDR), and unspecific toxicity. Nanoemulsions might be the solution to achieve efficient and safe tumor treatment. These formulations not only solve water-solubility problems but also provide specific targeting to cancer cells and might even be designed to overcome MDR. Nanoemulsions can be modified using ligands of different natures to target components present in tumor cells surface or to escape MDR mechanisms. Multifunctional nanoemulsions are being studied by a wide variety of researchers in different research areas mainly for the treatment of different types of cancer. All of these studies demonstrate that nanoemulsions are efficiently taken by the tumoral cells, reduce tumor growth, eliminate toxicity to healthy cells, and decrease migration of cancer cells to other organs.

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Chinese White Wax Solid Lipid Nanoparticles as a Novel Nanocarrier of Curcumin for Inhibiting the Formation of Staphylococcus aureus Biofilms

Cited by 23 publications

References 44 publications

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

Curcumin nanoformulations for antimicrobial and wound healing purposes

Current Applications of Nanoemulsions in Cancer Therapeutics

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