Development of hollow ferrogadolinium nanonetworks for dual-modal MRI guided cancer chemotherapy

Abstract

This multifunctional nanomaterial with a nanonetwork architecture can be used for dual-modal MRI guided cancer chemotherapy.

Shape programmable T1–T2 dual-mode MRI nanoprobes for cancer theranostics

“…Tang et al prepared a hollow porous ferrogadolinium nanonetwork structure by a one-pot solvothermal method and loaded it with cisplatin or commonly used anticancer drugs. 93 Gd 3+ is located inside the nanoplatform and has a parallel spin order in the same direction as the magnetic field induced by the Fe. After the nanomaterials participated in the blood circulation, the nanomaterials were mainly distributed in the liver, and the liver sections showed no pathological changes, which further confirmed that the hollow nanomaterials had low toxicity in vivo .…”

Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics

“…Staphylococcal killing by gentamicin was significantly (4–6‐fold) enhanced through improved penetration of gentamicin through the artificial channels. Since MIONPs have been demonstrated here and described in the literature as fully biocompatible, the current observations should be further advanced to clinical application. Moreover, there are no reasons to assume why the advantages of magnetically dug, artificial channels in biofilms would be confined to gentamicin.…”