Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS

Ma, Qingkun; Uchibe, Aoi; Shi, Qing; Toyo’oka, Toshimasa; Xu, Chunyan; Min, Jun Zhe

doi:10.2116/analsci.18scp09

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…So far, a number of methods have been explored to detect His or its metabolites alone, such as the colorimetric method for the detection of His and Hi, , the fluorometric method for the detection of His and Hi, , chromatography for the detection of His, the electrochemical method for the detection of His and Hi, , lateral flow immunoassay for the detection of Hi, and immunochromatographic method for the detection of Hi . Liquid chromatography coupled with electrospray mass spectrometry , was reported for simultaneous detection and discrimination of His and its metabolites in complex media. However, it often suffers from the disadvantages of high cost, complicated instruments, and professional operations, which hinders its further applications.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Qian,

Liu,

Huo

et al. 2023

Anal. Chem.

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Histidine (His) and its metabolite analysis is significant due to their vital roles in the diagnosis of diseases. In practical applications, simple and effective detection and discrimination of these metabolic species are still a great challenge due to their highly similar structures. Herein, photoluminescence (PL)−electrochemiluminescence (ECL) dual-mode sensor arrays consisting of a series of sensing elements were proposed for simultaneous quantitation and accurate discrimination of His and its four key metabolites (including histamine, imidazole-4-acetic acid, N-acetylhistamine, and imidazole propionate). The sensing elements of these sensor arrays were constructed by employing two solvent iridium(III) complexes ([Ir(pbz) 2 (DMSO)Cl] and [Ir-(ppy) 2 (DMSO)Cl], pbz = 3-(2-pyridyl)benzoic acid, ppy = 2phenylpyridine) with excellent PL and ECL performances as cross-responsive sensing units. Based on diverse coordination abilities of the two complexes with the imidazole group of the five targets, PL and ECL responses of each sensing unit can be enhanced to various degrees, which generate unique fingerprint patterns for the corresponding targets. Through principal component analysis, the multifarious patterns (two-, three-, and four-element sensor arrays) can be transformed into simple visualization modes, from which His and its four key metabolites can be effectively discriminated against each other. Moreover, the quantitation of an individual metabolic species at different concentrations and the recognition of the mixtures with different ratios were also accurately achieved. Notably, His and its four key metabolites in urine can also be successfully discriminated by the as-fabricated sensor arrays, and the patients with kidney diseases can be identified clearly, providing a promising way for disease diagnosis.

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Section: Introductionmentioning

confidence: 99%

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Qian,

Liu,

Huo

et al. 2023

Anal. Chem.

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Development of a method to evaluate the effects of external environments on drug stability in nails using micro‐segmental analysis

Kuwayama,

Miyaguchi,

Kanamori

et al. 2024

Drug Testing and Analysis

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Nails can be used as an alternative to hair for examining past drug use. However, daily hand‐and‐nail care can eliminate the internal drugs. Therefore, we developed an evaluation method to examine the effects of the external environment on drug stability in nails using micro‐segmental analysis. First, reference nails containing drugs were prepared by collecting fingernails from participants who had consumed hay‐fever medicines continuously for 4 months. Next, the entire free edge of a reference nail was cut into halves at the centerline; one side was stored as an untreated block, and the other was treated with various hand/nail care products. Both nail blocks were washed and segmented at 0.5‐mm intervals in the width direction. Each segment in the extraction solution was crushed with stainless‐steel beads, sonicated, and soaked in the solution for 24 h. The analytes in extracts were quantified by LC–MS/MS, and the drug concentrations between the treated and untreated blocks were compared. The drug concentrations decreased slightly in nails treated with manicure and gel‐nail products. The analytes in nails tended to be lower in water‐rich products such as hand soap and hand cream than in oil‐rich products such as nailcare oil and acetone‐free remover. The developed method using micro‐segmental analysis enabled the evaluation of the effects of various hand/nail care products on drug stability in a limited number of nails. This would also be useful for examining the effects of severe environments on drugs in nails collected from cases of unnatural death.

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Analysis of Endogenous Metabolites in Human Matrices

Struck-Lewicka

Macioszek

Artymowicz

et al. 2022

Handbook of Bioanalytics

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Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS

Cited by 8 publications

References 28 publications

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Development of a method to evaluate the effects of external environments on drug stability in nails using micro‐segmental analysis

Analysis of Endogenous Metabolites in Human Matrices

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