Development of highly biocompatible Gelatin &amp; i-Carrageenan based composite hydrogels: In depth physiochemical analysis for biomedical applications

Padhi, Jyostna Rani; Nayak, Debasis; Nanda, Arpita; Rauta, Pradipta Ranjan; Ashe, Sarbani; Nayak, Bismita

doi:10.1016/j.carbpol.2016.07.098

Cited by 42 publications

(15 citation statements)

References 32 publications

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“…The reason for this behavior is that the cross-linker forms physical entanglement between the polymers of hydrogel. The influence of increasing cross-linking can be described by decrease in mesh size of network (Atta & Abdel-Azim, 1998 ; Padhi et al., 2016 ). Three main reasons due to which amount of GA decreases the swelling behavior of hydrogel are (a) the amino group of polymers are mainly responsible for the swelling behavior and the cross-linker mainly conceals the amino group thus decreasing the ability of polymer to swell (b) the other reason is that higher cross-linking reduces the process of ionization which is also responsible for swelling of polymers of hydrogel (c) higher concentration of cross-linker decreases the relaxation of polymer chains resulting in lesser swelling of hydrogels (Mirzaei et al., 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

et al. 2018

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The current study aimed to rationally develop and characterize pH-sensitive controlled release hydrogels by graft polymerization of gelatin (Gel) and hydroxypropyl methyl cellulose (HPMC) in the presence of glutaraldehyde (GA) using quetiapine fumarate for the treatment of schizophrenia. The prepared hydrogels discs were subjected to various physicochemical studies including: swelling, diffusion, porosity, sol-gel analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Three different pH values (1.2, 6.8 and 7.4) were used to determine shape, transition, and controlled release behavior of prepared hydrogels. Various kinetic models including zero order, first order, Higuchi model and Power Law equation were applied on drug release data. The optimized hydrogels were subjected to in vivo studies using albino rabbits. Swelling and release results were found to be insignificant (p < .05) evidencing that there was no significant difference in swelling and drug release rate of hydrogels in different pH mediums. Swelling, porosity, gel-fraction, and drug released (%) were found to be dependent on concentrations of Gel, HPMC, and GA. Kinetic models revealed that QTP-F release followed non-Fickian diffusion. In-vivo studies contributed significantly higher plasma QTP-F concentration (C max), time for maximum plasma concentration (T max), area under the curve (AUC0–inf) and half-life (t 1/2) as 18.32 ± 0.50 µg/ml, 8.00 ± 0.01 hrs, 6021.2 ± 5.09 µg.hrs/ml and 10.06 ± 0.43 hrs, respectively, for test-hydrogels when compared to reference market brand (Qusel® 200 mg, Hilton Pharma, Karachi, Pakistan) QTP-F tablets. It might be concluded that QTP-F loaded pH-sensitive hydrogels were developed successfully with reduced dosing frequency for schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

et al. 2018

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“…Such a difference in size could be attributed to the different preparation and analysis methods for AuNPs‐HG‐1 and AuNPs‐3 . Additionally, a broad peak was also observed at 21.26° due to the presence of inorganic, organic, and gelatin matters in the HG . In the XRD pattern for AuNPs‐HG‐2 , four distinct diffraction peaks at 38.39°, 44.51°, 64.78°, and 78.18° are also observed, which clearly confirms the presence of AuNPs in AuNPs‐HG‐2 .…”

Section: Resultsmentioning

confidence: 54%

“…To further confirm the presence of Au 0 particles, the XRD analysis was carried out for HG and three AuNP composites of HGs. In the XRD pattern of HG (Figure S14, Supporting Information), only one broad peak was observed at 22.17°, which is assigned as “broad halo” structure usually associated with amorphous substances . As shown in Figure , the XRD pattern for AuNPs‐HG‐1 reveals four distinct diffraction peaks at 38.23°, 44.38°, 64.52°, and 77.55° that could be accurately indexed to the (111), (200), (220), and (311) planes with face‐centered cubic crystalline structure of AuNPs (Joint Committee on Powder Diffraction Standards File No.01–089‐3697) .…”

Section: Resultsmentioning

confidence: 98%

AuNPs composites of gelatin hydrogels crosslinked by ferrocene‐containing polymer as recyclable supported catalysts

Long

Song

Shi

et al. 2019

J of Applied Polymer Sci

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To fabricate a recyclable supported catalyst based on gold nanoparticles (AuNPs) and gelatin hydrogel (HG) composites, a ferrocene (Fc)-containing tetrablock copolymer [P(NCHO-b-NFc-b-NTEG-b-NCHO)] was used as both reducing and stabilizing agents for AuNPs and as a crosslinker for HG. First, the effects of Fc-containing polymers, including homopolymer PNFc and copolymer P(NCHO-b-NFc-b-NTEG-b-NCHO), and different solvent systems on the morphology and aggregation of AuNPs were examined by using ultraviolet-visible spectroscopy, transmission electron microscopy, and dynamic light scattering. Second, two strategies (blending and soaking) were applied to prepare different AuNPs/HG composites (AuNPs-HG), and their structure and properties were studied by using various techniques including scanning electron microscopy, X-ray diffraction, and thermogravimetry. Finally, the catalytic performance and reusability of AuNPs-HG-1 (via blending) and AuNPs-HG-2 (via soaking) were evaluated utilizing the model catalytic reduction of 4-nitrophenol to 4-aminophenol by NaBH 4 . Results indicated that P(NCHO-b-NFc-b-NTEG-b-NCHO) dissolved in N,Ndimethylformamide was the optimal reductant and stabilizer to prepare AuNPs. The in situ reduction of Au III ions to Au 0 particles was very essential for the fabrication of AuNPs-HG in terms of hydrogel pore size, Au 0 distribution and immobilization stability, and hydrogel thermal stability. Due to the stronger interactions among AuNPs, P(NCHO-b-NFc-b-NTEG-b-NCHO), and gelatin molecules in the blending strategy, AuNPs-HG-1 showed better mechanical stability and catalytic performance and more reusing cycles than AuNPs-HG-2. This work highlights the design and fabrication of robust recyclable supported AuNP catalyst by using eco-friendly Fccontaining HGs.

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“…The major applications in the field of biomedicine are shown as a schematic layout in Figure 6 . CGs are applied in various pharmaceutical formulations, including tablets [ 106 , 108 ], suppositories [ 109 , 110 ], films [ 111 ], fast-dissolving inserts (FDIs) [ 63 ], beads [ 112 , 113 ], pellets [ 114 , 115 , 116 ], microparticles [ 117 , 118 , 119 ], nanoparticles [ 120 , 121 , 122 , 123 , 124 , 125 ], inhalable systems, injectables [ 126 ], and hydrogels [ 127 , 128 , 129 ]. In addition, recent studies have shown that CGs are promising candidates in tissue engineering, thanks to their similarity to native glycosaminoglycans [ 127 , 128 , 130 , 131 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

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Development of highly biocompatible Gelatin & i-Carrageenan based composite hydrogels: In depth physiochemical analysis for biomedical applications

Cited by 42 publications

References 32 publications

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

AuNPs composites of gelatin hydrogels crosslinked by ferrocene‐containing polymer as recyclable supported catalysts

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

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