Development of hemoglobin aquasomes from spherical hydroxyapatite cores precipitated in the presence of half-generation poly(amidoamine) dendrimer

Khopade, A. J.; Khopade, Surekha A.; Jain, Naresh C.

doi:10.1016/s0378-5173(02)00235-1

Cited by 67 publications

(51 citation statements)

References 22 publications

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“…One possibility is that PAMAM-MG serves as nucleation site, which leads to the binding of Ca 2? to the carboxylic acid groups on the PAMAM-MG surface. Such an interaction was reported by Khopade et al [25] and Zhou et al [18]. Zhou indicated that when -COOH-terminated PAMAM dendrimers were mixed with Ca 2?…”

Section: Crystal Morphologiessupporting

confidence: 64%

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

et al. 2010

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Second generation poly(amidoamine) (PAMAM) dendrimers were synthesized and peripherally modified with glutamic acid (PAMAM-MG) as a shell. The effect of the dendrimers on the crystallization of different calcium phosphate compounds was investigated in both double and one way diffusion systems. It was found that the crystals of calcium phosphate showed tape-like morphology in the presence of PAMAM-MG, and the crystals' thickness and width decreased compared to those grown without dendritic molecules. Such a result might be due to the interaction of electric charges between dendritic molecules and octacalcium phosphate (Ca 8 H 2 (PO 4 ) 6 Á5H 2 O, OCP), which led to the adsorption of PAMAM-MG in the 100 and 010 surfaces of OCP. Moreover, PAMAM-MG showed an affinity for gelatin, and it could cause the formation of amorphous calcium phosphate (Ca 9 (PO 4 ) 6 ÁnH 2 O, ACP) at a concentration of 5 mg/mL of PAMAM-MG. These results suggest that PAMAM-MG could be used for regulating the morphology of OCP and changing the composition of minerals in gels.

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Section: Crystal Morphologiessupporting

confidence: 64%

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

et al. 2010

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“…It was suggested that PAMAM-COOH might serve as the nucleation site due to calcium ion electrostatically binding on the carboxylic acid groups and might affect the morphology of HAP crystals as the growth inhibitor blocking the incorporation of mineral ions into the crystal surfaces [Khopade et al, 2002;Zhou et al, 2007]. That might be the same mechanism of enamel remineralization as was observed in this study.…”

Section: Discussionsupporting

confidence: 65%

Biomimetic Remineralization of Human Enamel in the Presence of Polyamidoamine Dendrimers in vitro

Chen

He²,

Tang³

et al. 2015

Caries Res

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Poly(amidoamine) (PAMAM) dendrimers, known as artificial proteins, have unique and well-defined molecular size and structure. It has previously been used to mimic protein-crystal interaction during biomineralization. In this study, generation 4.5 (4.5G) PAMAM with carboxylic acid (PAMAM-COOH) was synthesized and utilized to remineralize the surface of etched enamel in vitro. Using confocal laser scanning microscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis and scanning electron microscopy we observed that 4.5G PAMAM-COOH can be absorbed on the etched enamel surface and that it can induce the formation of hydroxyapatite crystals with the same orientation as that of the enamel prisms on longitudinal and transversal enamel surfaces. The self-assembly behavior of PAMAM in the mineralization solution was also investigated and the result showed that 4.5G PAMAM can assemble to microribbon structure similar to the behavior of amelogenins. Therefore, we concluded that 4.5G PAMAM-COOH assemblies can act as the organic template on enamel surface and in mineralization solution to control the nucleation site and morphology of new-grown crystals to form the biomimetic structure of human enamel, which may open a new way for repairing damaged enamel.

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“…4 of 17 the wet chemical method, A.J.Kkhopade et.al [32] and G.Han et.al [33] observed HAP particles with plate like structure or morphology in contrast to the spherical-shaped HAP produced when using ultrasonic irradiation.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method

Poinern

Brundavanam

Mondinos

et al. 2009

Ultrasonics Sonochemistry

153

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Nanostructured hydroxyapatite (HAP) was prepared by a wet precipitation method using Ca(NO 3 ) and KH 2 PO 4 as the main material and NH 3 as the precipitator under ultrasonic irradiation. The Ca/P ratio was set at 1.67 and the pH maintained at a minimum of 9. The temperature conditions and ultrasound influences were investigated using X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The results showed that Nano-HAP can be obtained by this method and the particles were achieved to around 30nm.

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Development of hemoglobin aquasomes from spherical hydroxyapatite cores precipitated in the presence of half-generation poly(amidoamine) dendrimer

Cited by 67 publications

References 22 publications

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

Biomimetic Remineralization of Human Enamel in the Presence of Polyamidoamine Dendrimers in vitro

Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method

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