Development of functionalized hydroxyapatite/poly(vinyl alcohol) composites

Stipniece, Liga; Šalma-Ancāne, Kristīne; Rjabovs, Vitālijs; Juhņeviča, Inna; Turks, Māris; Narkevica, Inga; Bērziņa-Cimdiņa, Līga

doi:10.1016/j.jcrysgro.2016.03.029

Cited by 19 publications

(12 citation statements)

References 34 publications

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“…The XRD patterns of pure PVA and PVA composites with and without HA are displayed in Figure 5a,b. In the pure PVA pattern, the intense characteristic peak at 2θ = 19.8° corresponding to a semi-crystalline structure [42,43]. The presence of the anatase phase of titania nanoparticles is also evidenced at about the same peak location as in Figure 2, along with the weak characteristic peaks of selenium and rutile, mainly emphasized in the samples PVA800.…”

Section: Xrd Patterns Of Pva Compositesmentioning

confidence: 73%

Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties

et al. 2020

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The properties of poly(vinyl alcohol) (PVA)-based composites recommend this material as a good candidate for the replacement of damaged cartilage, subchondral bone, meniscus, humeral joint and other orthopedic applications. The manufacturing process can be manipulated to generate the desired biomechanical properties. However, the main shortcomings of PVA hydrogels are related to poor strength and bioactivity. To overcome this situation, reinforcing elements are added to the PVA matrix. The aim of our work was to develop and characterize a novel composition based on PVA reinforced with Se-doped TiO2 nanoparticles and natural hydroxyapatite (HA), for possible orthopedic applications. The PVA/Se-doped TiO2 composites with and without HA were structurally investigated by FTIR and XRD, in order to confirm the incorporation of the inorganic phase in the polymeric structure, and by SEM and XRF, to evidence the ultrastructural details and dispersion of nanoparticles in the PVA matrix. Both the mechanical and structural properties of the composites demonstrated a synergic reinforcing effect of HA and Se-doped TiO2 nanoparticles. Moreover, the tailorable properties of the composites were proved by the viability and differentiation potential of the bone marrow mesenchymal stem cells (BMMSC) to osteogenic, chondrogenic and adipogenic lineages. The novel hybrid PVA composites show suitable structural, mechanical and biological features to be considered as a promising biomaterial for articular cartilage and subchondral bone repair.

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Section: Xrd Patterns Of Pva Compositesmentioning

confidence: 73%

Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties

et al. 2020

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“…The main characteristic peaks of PVA were 3280 cm −1 (O–H stretching vibration), 2960 cm –1 (CH 2 asymmetric stretching vibration), 2925 cm −1 (CH 2 symmetric stretching vibration), 1735 cm −1 (C=O carbonyl stretch), 1425 cm −1 (C–H bending vibration of CH 2 ), 1380 cm −1 (C–H deformation vibration), 1325 cm −1 (CH 2 wagging vibration), 1245 cm −1 (C–O–C stretching vibration), 1100 cm −1 (C–O stretching of acetyl groups), and 840 cm −1 (C−C stretching vibration) [ 25 , 27 , 28 ]. It was obvious that when the OH groups of the PVA backbone were modified by succinyl moieties, the OH-stretching band of pure PVA (~3280 cm −1 ) diminished, and the emergence of significant absorption bands at 1735 and 1670 cm −1 , which were associated with the esteric carbonyls and carboxylate moieties, respectively, characterized the difference between these two spectra [ 29 ]. The new peak at 1580 cm −1 was due to the asymmetric stretching vibration of carboxylate RCOO − [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Use of Self-Assembled Colloidal Prodrug Nanoparticles for Controlled Drug Delivery of Anticancer, Antifibrotic and Antibacterial Mitomycin

Abdelghafour

Deák

Szabó

et al. 2022

IJMS

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Herein we present the synthesis of a polymeric prodrug nanomaterial capable of spontaneous, self-assembled nanoparticle formation and of the conjugation (encapsulation) of drugs with amino and/or carboxyl and/or hydroxyl groups via ester and/or amide linkage. Mitomycin C (MMC) a versatile drug with antibiotic, antibacterial and antineoplastic properties, was used to prove this concept. The in vitro drug release experiments showed a fast release for the pure MMC (k = 49.59 h−n); however, a significantly lower MMC dissolution rate (k = 2.25, 1.46, and 1.35 h−n) was obtained for the nanoparticles with increased cross-link density (3, 10, 21%). The successful modification and conjugation reactions were confirmed using FTIR and EDX measurements, while the mucoadhesive properties of the self-assembled particles synthesized in a simple one-pot reaction were proved by rheological measurement. The prepared biocompatible polymeric prodrugs are very promising and applicable as a drug delivery system (DDS) and useful in the area of cancer treatment.

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“…No differences among SSA values of the as-dried microspheres were observed despite of various Mg content. Relatively high SSA of the asdried microspheres is associated with slit-shaped pore structure of the nanoparticle assemblies, which are characteristic to spray-dried HAp products [31][32][33]. In general, three distinct categories of spray-dried particle morphology are identified, namely, crystalline, skin forming and agglomerate.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of surface properties of Mg-substituted hydroxyapatite bioceramic microspheres

Stipniece

Stepanova

Narkevica

et al. 2018

Journal of the European Ceramic Society

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Mg-substituted hydroxyapatite (HAp) bioceramic microspheres were prepared by spray drying and subsequent processing at 1173, 1273 and 1373 K. Influence of various Mg substitution levels (up to 0.84 ± 0.10 wt%) on physicochemical properties of the HAp bioceramic microspheres was evaluated. Obtained results were used for the elucidation of the compositional and structural characteristics of the microspheres in conjunction with adsorption of protein, namely, bovine serum albumin (BSA). The primary difference among the microspheres processed at various temperature was the presence or absence of the micropores (< 2 nm in diameter) and mesopores (between 2 and 50 nm). Presence of the micro-and mesopores resulted in higher specific surface area (SSA), enhanced solubility, i.e., ion release, and, accordingly, increase in the amount of BSA adsorbed on the microspheres. Furthermore, the BSA adsorption capacity of the microspheres decreased with increasing Mg content despite of higher SSA.

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Development of functionalized hydroxyapatite/poly(vinyl alcohol) composites

Cited by 19 publications

References 34 publications

Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties

Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties

Use of Self-Assembled Colloidal Prodrug Nanoparticles for Controlled Drug Delivery of Anticancer, Antifibrotic and Antibacterial Mitomycin

Comparative study of surface properties of Mg-substituted hydroxyapatite bioceramic microspheres

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