Development of extended-voyaging anti-oxidant Linked Amphiphilic Polymeric Nanomicelles for Anti-Tuberculosis Drug Delivery

Praphakar, Rajendran Amarnath; Munusamy, Murugan A.; Rajan, Mariappan

doi:10.1016/j.ijpharm.2017.03.089

Cited by 52 publications

(15 citation statements)

References 47 publications

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“…Amphiphilic polymers of chitosan with ɛ-caprolactone and covalently bonded ferulic acid were prepared for the targeted delivery of antitubercular drugs by Praphakar et al [ 90 ]. Poornima and Korrapati [ 91 ] developed innovative nanofibers based on the polycaprolactone-grafted chitosan for the simultaneous delivery of ferulic acid and resveratrol.…”

Section: Novel Strategies For Ferulic Acid Drug Deliverymentioning

confidence: 99%

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Stompor-Gorący

Machaczka

2021

IJMS

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Trans-ferulic acid (FA) is a derivative of 4-hydroxycinnamic acid, which is found in many food products, fruits and beverages. It has scientifically proven antioxidant, anti-inflammatory and antibacterial properties. However, its low ability to permeate through biological barriers (e.g., the blood–brain barrier, BBB), its low bioavailability and its fast elimination from the gastrointestinal tract after oral administration limit its clinical use, e.g., for the treatment of neurodegenerative diseases, such as Alzheimer’s disease. Therefore, new nanotechnological approaches are developed in order to regulate intracellular transport of ferulic acid. The objective of this review is to summarize the last decade’s research on biological properties of ferulic acid and innovative ways of its delivery, supporting pharmacological therapy.

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Section: Novel Strategies For Ferulic Acid Drug Deliverymentioning

confidence: 99%

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Stompor-Gorący

Machaczka

2021

IJMS

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“…Debido a su biocompatibilidad, estabilidad estructural, alta capacidad de transportar medicamentos en su superficie externa y de solubilizar medicamentos hidrofóbicos en su núcleo interno, tienen ventajas sobre otras NP para transportar diversos tipos de fármacos. Detalles sobre la evaluación de estas NP para transportar rifampicina se puede encontrar en la Tabla 5 (45)(46)(47)(48)(49) .…”

Section: Nanomicela (Nmc)unclassified

Nanopartículas como transportadores de fármacos: una herramienta prometedora contra la tuberculosis

Luna-Herrera

Pérez-Martínez

Barradas-Hernández

et al. 2021

Rev Peru Med Exp Salud Publica

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La Organización Mundial de la Salud (OMS) ubica a la tuberculosis (TB) como uno de los problemas de salud más preocupantes en la actualidad, y señala que se requieren de acciones novedosas para controlar su expansión y, de esta manera, alcanzar una de las metas establecidas en los Objetivos de Desarrollo Sostenible: reducir para 2030 la morbilidad e incidencia de TB. Para lograr este objetivo, está claro que las herramientas empleadas actualmente para su diagnóstico y tratamiento ya no son las adecuadas. En este sentido, es necesario desarrollar nuevos medicamentos y vacunas, así como novedosos procedimientos de administración de fármacos que generen una mejor respuesta, disminuyan el tiempo y optimicen los tratamientos. La nanotecnología ha incorporado en los últimos años un gran número de nuevas herramientas que incrementan considerablemente, la diversidad de mecanismos para la administración de tratamientos antituberculosos. Dicho esto, la presente revisión describe brevemente el estado actual de la farmacorresistencia en TB, así como las características generales de las nanopartículas que están evaluándose como herramientas para transportar antibióticos antituberculosos.

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“…Polymeric NPs have garnered speculations attributable to their remarkable credentials such as passive deposition in the target site, biocompatibility, physicochemical stability, and modified release. Furthermore, the hydrophilic outer core and hydrophobic inner core allow for varied drugs to be entrapped within it [20]. All these abilities explicitly justify the use of NPs in TB therapy.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Micelles have principally been explored for hydrophobic drugs attributable to their amphiphilic nature [75]. Tripodo et al tailored micelles of RIF based on inulin modified with vitamin E. The MIC values obtained post formulation administration showed superior activity against bacterial strains as compared with free drug.…”

Section: Micellesmentioning

confidence: 99%

Nano-based anti-tubercular drug delivery: an emerging paradigm for improved therapeutic intervention

Nabi

Rehman

Aggarwal

et al. 2020

Drug Deliv. and Transl. Res.

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Tuberculosis (TB) classified as one of the most fatal contagious diseases is of prime concern globally. Mycobacterium tuberculosis is the causative agent that ingresses within the host cells. The approved conventional regimen, though the only viable option available, is unfavorably impacting the quality of life of the affected individual. Despite newer antibiotics gaining light, there is an unending demand for more therapeutic alternatives. Therefore, substantial continuous endeavors are been undertaken to come up with novel strategies to curb the disease, the stepping stone being nanotechnology. This approach is instrumental in overcoming the anomalies associated with conventional therapy owing to their intriguing attributes and leads to optimization of the therapeutic effect to a certain extent. This review focusses on the different types of nanocarrier systems that are being currently explored by the researchers for the delivery of anti-tubercular drugs, the outcomes achieved by them, and their prospects.

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Development of extended-voyaging anti-oxidant Linked Amphiphilic Polymeric Nanomicelles for Anti-Tuberculosis Drug Delivery

Cited by 52 publications

References 47 publications

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Nanopartículas como transportadores de fármacos: una herramienta prometedora contra la tuberculosis

Nano-based anti-tubercular drug delivery: an emerging paradigm for improved therapeutic intervention

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