Development of esterase activities in the chicken before and after hatching

Farage-Elawar, Miranda

doi:10.1016/0892-0362(91)90004-g

Cited by 13 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significant differences between oseltamivir and zanamivir were not found in any experiment although zanamivir is active at the site of viral replication and the prodrug oseltamivir phosphate has to undergo metabolic conversion via esterase hydrolysis to the active oseltamivir carboxylate [10]. Our findings suggest that carboxylesterases, which have been detected in the liver and the blood of chick embryos by day 10 of incubation [5], have the capacity to convert oseltamivir into NA inhibitor within a short time interval. However, it cannot be excluded whether the use of the NA inhibitor oseltamivir carboxylate, which was not available for this study, would have induced a higher level of protection.…”

Section: Discussioncontrasting

confidence: 47%

Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors

Sauerbrei

Haertl

Brandstaedt

et al. 2005

Med Microbiol Immunol

View full text Add to dashboard Cite

Previous studies have shown that embryonated egg provides a convenient and easy to use system for in vivo screening of anti-influenza virus inhibitors. However, it is not known whether this model is suitable for testing neuraminidase (NA) inhibitors, too. Therefore, the present study describes the evaluation of the ion-channel blockers amantadine and rimantadine in comparison with the NA inhibitors oseltamivir and zanamivir by using the influenza A virus hen's egg model. The treatment was started immediately before or after the challenge dose was placed on the chorioallantoic membrane (CAM). Differences between the survival rate of treated and untreated chick embryos infected with influenza A virus were analyzed statistically. As result, the survival rate of chick embryos could be significantly increased when the treatment with amantadine, rimantadine, oseltamivir, or zanamivir was started before the CAM was inoculated with one egg infective dose 50% (EID50) influenza A virus. When the drugs were administered shortly after viral inoculation, significant antiviral efficacy was shown for rimantadine, oseltamivir, and zanamivir. Antiviral efficacy could be demonstrated exclusively for both oseltamivir and zanamivir after the embryos were infected with higher challenge doses of 10(2) EID50 influenza A virus. In conclusion, the NA inhibitors oseltamivir and zanamivir have a significantly better antiviral activity against influenza A virus than amantadine and rimantadine tested in embryonated hen's eggs. Therefore, this model can be a valuable alternative approach for in vivo pre-testing anti-influenza virus activity of NA inhibitors.

show abstract

Section: Discussioncontrasting

confidence: 47%

Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors

Sauerbrei

Haertl

Brandstaedt

et al. 2005

Med Microbiol Immunol

View full text Add to dashboard Cite

show abstract

“…chick embryo nervous systems. 14,24 It was also reported that in rodents there is a relationship between TH and AChE, 25 between disorders of thyroid function and cognitive decline, 5,6 and that hypothyroid adult rats show a decline of AChE activity in the cerebellum. 25 TH activity is thought to be carried out in the brain of chick embryo via THR function.…”

Section: Discussionmentioning

confidence: 93%

“…Recently, the cerebellum has been demonstrated to be involved in cognition, and to be implicated in psychiatric illness in general, 21,22 in addition to its traditionally ascribed functions, such as coordination, balance, gait and fine motor control. It has been suggested that AChE, independently of its catalytic function, is involved in the regulation of cell proliferation and neurite growth during the development of rat 23 and the chick embryo nervous systems 14,24 . It was also reported that in rodents there is a relationship between TH and AChE, 25 between disorders of thyroid function and cognitive decline, 5,6 and that hypothyroid adult rats show a decline of AChE activity in the cerebellum 25 .…”

Section: Discussionmentioning

confidence: 99%

Effect of antithyroid drug on chick embryos during the last week of development: Delayed hatching and decreased cerebellar acetylcholinesterase activity

Haba¹,

Nishigori²,

Tezuka

et al. 2011

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…If the source of AChE activity in plasma is the brain, maturation of the blood-brain barrier would reduce the transfer of AChE, resulting in decreased activity in plasma with age. Alternatively, the decline in AChE activity in plasma may be the result of a decline in AChE in muscle as muscle fiber matures (Smucker and Wilson, 1990;Farage-Elawar, 1991). Further research is necessary to fully understand the origins of ChE activity in plasma of avian species.…”

Section: In Blackbirdsmentioning

confidence: 99%

Age-Dependent Changes in Plasma and Brain Cholinesterase Activities of House Wrens and European Starlings

Mayack

Martin

2003

Journal of Wildlife Diseases

View full text Add to dashboard Cite

We determined age-dependent changes in plasma and brain cholinesterase (ChE) activity for two species of passerines: house wren (Troglodytes aedon) and European starling (Sturnus vulgaris, starling). In plasma from nestlings of both species, total ChE activity increased with age, acetycholinesterase (AChE, EC 3.1.1.7) activity declined rapidly immediately after hatching, and butyrylcholinesterase (BChE, EC 3.1.1.8) activity increased steadily. For both species, total ChE and BChE activities and the BChE:AChE ratio in plasma were significantly greater in adults than nestlings suggesting trends observed in nestlings continue post fledging. In older nestlings and adults, AChE activity in plasma was significantly greater and BChE:AChE ratio less in house wrens than starlings. For house wrens as compared with starlings, ChE activity in brain increased at a significantly greater rate with age in nestlings and was significantly greater in adults. However, ChE activity in brain was similar at fledging for both species suggesting that the increase in ChE in brain is more directly related to ontogeny than chronologic age in nestlings of passerines. For both species, ChE activity increased significantly with brain weight of nestlings but not adults. House wrens hold similar patterns of age-dependent change in ChE activity in common with starlings but also exhibit differences in AChE activity in plasma that should be considered as a factor potentially affecting their relative toxicologic response to ChE inhibitors.

show abstract

Development of esterase activities in the chicken before and after hatching

Cited by 13 publications

References 39 publications

Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors

Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors

Effect of antithyroid drug on chick embryos during the last week of development: Delayed hatching and decreased cerebellar acetylcholinesterase activity

Age-Dependent Changes in Plasma and Brain Cholinesterase Activities of House Wrens and European Starlings

Contact Info

Product

Resources

About