Effect of antithyroid drug on chick embryos during the last week of development: Delayed hatching and decreased cerebellar acetylcholinesterase activity

Haba, Gen; Nishigori, Hidekazu; Tezuka, Yu; Kagami, Keisuke; Sugiyama, Toru; Nishigori, Hideo

doi:10.1111/j.1447-0756.2011.01573.x

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…Moreover, the hatching rate was strikingly low in the MMI-treated group and this was deemed significant, not only statistically, but also physiologically. This result is in line with the observation that chicken embryos have been reported to have delayed hatching upon exposure to MMI (Haba et al, 2011). Interestingly, another compound shown to affect zebrafish hatching rate is perfluorooctanoic acid (PFOA), an established thyroid-active compound (lopez-espinosa et al, 2012;Melzer et al, 2010;Zheng et al, 2011).…”

Section: Discussionsupporting

confidence: 69%

Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test

Jomaa

Hermsen

Kessels

et al. 2014

ALTEX

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Section: Discussionsupporting

confidence: 69%

Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test

Jomaa

Hermsen

Kessels

et al. 2014

ALTEX

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“…Likewise, altering levels of SF1, NR5A2, ESRRβ, and several members of the SMAD and LHX families were also detected in the chick ovaries during embryonic to post-hatching transition (Oreal et al, 2002;Ghafari et al, 2007;Carre et al, 2011). In contrast, information about the functions of NF1, THRβ, and the TEAD family remains scarce in the avian ovary, all of which were evidenced to be involved in regulating cell survival, proliferation, and adhesion partially by acting as components of multiple signal transduction (e.g., the Hippo and Ras-MEK/Akt) pathways and some of which were expressed in a variety of tissues of the chick embryos (Schafer et al, 1993;Cao et al, 2008;Haba et al, 2011). Significantly, expression of these transcription factors in embryonic and post-hatching geese ovaries was determined by RNA-seq and qRT-PCR.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of the Transcriptome and Accessible Chromatin Landscapes During Early Goose Ovarian Development

Yang

et al. 2020

Front. Cell Dev. Biol.

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In contrast to the situation in mammals, very little is known about the molecular mechanisms regulating early avian ovarian development. This study aimed to investigate the dynamic changes in the histomorphology as well as the genome-wide transcriptome and chromatin accessibility landscapes of the goose ovary during late embryonic and early post-hatching stages. Results from hematoxylin-eosin, periodic acid-Schiff, and anti-CVH immunohistochemical stainings demonstrated that programmed oocyte loss, oocyte nest breakdown and primordial follicle formation, and the primordial-tosecondary follicle transition occur during the periods from embryonic day 15 (E15) to post-hatching day 0 (P0), from P0 to P4, and from P4 to P28, respectively. RNA-seq and ATAC-seq analyses revealed dynamic changes in both the ovarian transcriptome and accessible chromatin landscapes during early ovarian development, exhibiting the most extensive changes during peri-hatching oocyte loss, and moreover, differences were also identified in the genomic distribution of the differential ATACseq peaks between different developmental stages, suggesting that chromatin-level regulation of gene expression is facilitated by modulating the accessibility of different functional genomic regions to transcription factors. Motif analysis of developmental stage-selective peak regions identified hundreds of potential cis-regulatory elements that contain binding sites for many transcription factors, including SF1, NR5A2, ESRRβ, NF1, and THRβ, as well as members of the GATA, SMAD, and LHX families, whose expression fluctuated throughout early goose ovarian development. Integrated ATACseq and RNA-seq analysis suggested that the number and genomic distribution of the newly appeared and disappeared peaks differed according to developmental stage, and in combination with qRT-PCR validation potentiated the critical actions of the DEGs enriched in cell cycle, MAPK signaling, and FoxO signaling pathways during peri-hatching oocyte loss and those in ligand-receptor interaction, tissue remodeling, lipid metabolism, and Wnt signaling during primordial follicle formation and development.

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“…Hatching is delayed or even inhibited in embryos treated with different TH inhibitors. Furthermore, an administration of TH into the egg retracts the yolk sac and shortens the incubation time [ 18 , 33 , 34 , 35 , 36 , 37 ]. Based on findings from earlier studies it is therefore likely that the difference in incubation time seen in the TSHR chickens is caused by altered TH levels due to the mutation in the TSHR d/d genotype.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Mutation in the Thyroid Stimulating Hormone Receptor (TSHR) on Development, Behaviour and TH Levels in Domesticated Chickens

et al. 2015

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The thyroid stimulating hormone receptor (TSHR) has been suggested to be a “domestication locus” in the chicken, due to a strong selective sweep over the gene found in domesticated chickens, differentiating them from their wild ancestor the Red Junglefowl (RJF). We investigated the effect of the mutation on development (incubation time), behaviour and thyroid hormone levels in intercross chickens homozygous for the mutation (d/d), wild type homozygotes (w/w) or heterozygotes (d/w). This allowed an assessment of the effect of genotype at this locus against a random mix of RJF and WL genotypes throughout the rest of the genome, controlling for family effects. The d/d genotype showed a longer incubation time, less fearful behaviours, lower number of aggressive behaviours and decreased levels of the thyroid hormone T4, in comparison to the w/w genotype. The difference between TSHR genotypes (d/d vs. w/w) in these respects mirrors the differences in development and behaviour between pure domesticated White Leghorns and pure RJF chickens. Higher individual T3 and T4 levels were associated with more aggression. Our study indicates that the TSHR mutation affects typical domestication traits, possibly through modifying plasma levels of thyroid hormones, and may therefore have been important during the evolution of the domestic chicken.

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Effect of antithyroid drug on chick embryos during the last week of development: Delayed hatching and decreased cerebellar acetylcholinesterase activity

Cited by 16 publications

References 30 publications

Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test

Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test

Dynamics of the Transcriptome and Accessible Chromatin Landscapes During Early Goose Ovarian Development

The Effect of a Mutation in the Thyroid Stimulating Hormone Receptor (TSHR) on Development, Behaviour and TH Levels in Domesticated Chickens

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