Development of Electrophoretic Methods for Simultaneous Determination of Enantiomeric Ratio and Composition of Diastereomeric Salt Mixtures

Varga, Erzsébet; Sohajda, Tamás; Juvancz, Zoltán; Kendrovics, Rita Bodáné; Székely, Edit; Bánsághi, György

doi:10.1007/s10337-015-2923-x

Cited by 8 publications

(12 citation statements)

References 22 publications

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“…An overview of EKC‐UV methods applicable for quality control of pharmaceuticals published since 2015 is provided in Table 3 [71–106]. The most frequently, CDs were used as chiral selectors in these works, owning to their advantages, such as low cost, good stability, low UV cut‐off, high water solubility, and excellent chiral selectivity.…”

Section: Electrokinetic Chromatographymentioning

confidence: 99%

“…Evaluation of extraction efficiency, conversion, and enantioselectivity achieved within the preparation of enantiopure ibuprofen in a resolvation experiment via diastereomeric salt formation was reported by Varga et al. [84]. The separation of ibuprofen enantiomers and resolving agent phenylethylamine was achieved using permethylated‐β‐CD as a chiral selector.…”

Section: Electrokinetic Chromatographymentioning

confidence: 99%

“…Carboxymethyl-β-CD, sulfated-β-CD, dimethyl-β-CD, and hydroxypropyl-β-CD provided satisfactory resolution values for all enantiomers of individually injected API or impurities; however, only carboxymethyl-β-CD enabled simultaneous enantioseparation of ofloxacin and two of the related substances. Evaluation of extraction efficiency, conversion, and enantioselectivity achieved within the preparation of enantiopure ibuprofen in a resolvation experiment via diastereomeric salt formation was reported by Varga et al [84]. The separation of ibuprofen enantiomers and resolving agent phenylethylamine was achieved using permethylatedβ-CD as a chiral selector.…”

Section: Ekc-uvmentioning

confidence: 99%

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Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Řemínek

Foret

2020

Electrophoresis

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Capillary electrophoresis represents a promising technique in the field of pharmaceutical analysis. The presented review provides a summary of capillary electrophoretic methods suitable for routine quality control analyses of small molecule drugs published since 2015. In total, more than 80 discussed methods are sorted into three main sections according to the applied electroseparation modes (capillary zone electrophoresis, electrokinetic chromatography, and micellar, microemulsion, and liposome-electrokinetic chromatography) and further subsections according to the applied detection techniques (UV, capacitively coupled contactless conductivity detection, and mass spectrometry). Key parameters of the procedures are summarized in four concise tables. The presented applications cover analyses of active pharmaceutical ingredients and their related substances such as degradation products or enantiomeric impurities. The contribution of reported results to the current knowledge of separation science and general aspects of the practical applications of capillary electrophoretic methods are also discussed.

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Section: Electrokinetic Chromatographymentioning

confidence: 99%

Section: Electrokinetic Chromatographymentioning

confidence: 99%

Section: Ekc-uvmentioning

confidence: 99%

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Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Řemínek

Foret

2020

Electrophoresis

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“…In a different study, Varga et al. developed a method for the simultaneous determination of enantiomeric ratio and composition of diastereomeric salt mixtures. Briefly, a modified Pope‐Peachy method with diastereomeric salt formation was performed in order to obtain enantiomerically pure compounds.…”

Section: Chiral Selectorsmentioning

confidence: 99%

Chiral selectors in CE: Recent development and applications (mid‐2014 to mid‐2016)

Stavrou

Agathokleous

Kapnissi‐Christodoulou

2017

Electrophoresis

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This report, which is a sequence of a series of reviews, records the most important chiral selectors (CSs) applied in CE. It highlights the CSs that were used during the period 2014 to mid-2016. In this review, method developments, validations, and pharmaceutical along with biomedical applications are presented. The different CSs include CDs, antibiotics, cyclofructants, linear and branched oligo- and polysaccharides, and polymeric surfactants. In addition, the advantages of these CSs, along with their chiral recognition mechanisms, and their performance, are discussed.

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“…Varga et al. demonstrated the feasibility of the approach using cis ‐permethrinic acid and ibuprofen as model compounds which were resolved via crystallization with R ‐1‐phenylethalamine . The analytical enantioseparation of the compounds was achieved in a fused‐silica capillary using a 50 mM Britton‐Robinson buffer with a pH between 7.0 and 7.2 depending on the analyte using 10 to 12.5 mM TM‐β‐CD as chiral selector.…”

Section: Separation and Analysis Of Small Moleculesmentioning

confidence: 99%

Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013–2015)

et al. 2016

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This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. General approaches such as quality by design as well as sample injection methods and detection sensitivity are discussed. The separation and analysis of drug-related substances, chiral CE, and chiral CE-MS in addition to the determination of physicochemical constants are addressed. The advantages of applying affinity capillary electrophoresis in studying receptor-ligand interactions are highlighted. Finally, current aspects related to the analysis of biopharmaceuticals are reviewed. The present review covers the literature between January 2013 and December 2015.

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Development of Electrophoretic Methods for Simultaneous Determination of Enantiomeric Ratio and Composition of Diastereomeric Salt Mixtures

Cited by 8 publications

References 22 publications

Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Chiral selectors in CE: Recent development and applications (mid‐2014 to mid‐2016)

Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis (2013–2015)

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