2013
DOI: 10.14356/kona.2013004 View full text |Buy / Rent full text
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Abstract: The photo shows the "stent" coated with "biocompatible and bioabsorbable poly (D, L-lactide-co-glycolide) (PLGA) nanoparticles (NPs)" which are known to have advanced DDS functions such as the sustained-release by its hydrolysis property and the intracellular delivery by its small size effect. "Stent" is a medical device formed of metallic meshed tube and used as a measure to treat the stenosis of the artery to improve the blood flow by eternal expanding and supporting of the blood vessels.The use of a bare me… Show more

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“…For the base polymer, we chose a poly(lactic-co-glycolic acid) (PLGA), with the lactic/glycolic ratio being 50:50. It is a biocompatible and biodegradable polymer widely used in the coating of medical devices and in medicine in general, including particles and implants [ 2 , 14 , 15 ]. PLGA exhibits a strong tendency to hydrolysis and will degrade gradually in a course of a few months within the aquatic medium [ 16 ].…”
Section: Introductionmentioning
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“…For the base polymer, we chose a poly(lactic-co-glycolic acid) (PLGA), with the lactic/glycolic ratio being 50:50. It is a biocompatible and biodegradable polymer widely used in the coating of medical devices and in medicine in general, including particles and implants [ 2 , 14 , 15 ]. PLGA exhibits a strong tendency to hydrolysis and will degrade gradually in a course of a few months within the aquatic medium [ 16 ].…”
Section: Introductionmentioning