Development of DMD-based micro-stereolithography apparatus for biodegradable multi-material micro-needle fabrication

Yun, Haeyong; Kim, Ho-Chan

doi:10.1007/s12206-013-0812-5

Cited by 19 publications

(11 citation statements)

References 16 publications

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“…Therefore, in addition to guaranteeing the accuracy, the PµSL reduces the cost of construction and maintenance. Currently, a variety of materials are being used for the PµSL, including polymers, shape-memory polymers, ceramics, and biomaterials, which have increased its applications in various fields such as micro-optics 14 , metamaterials 15,16 , microfluidics 17–20 , tissue engineering 8,12,21–25 , and biomedical microdevices 26,27 .…”

Section: Introductionmentioning

confidence: 99%

A compact LED-based projection microstereolithography for producing 3D microstructures

Behroodi

Latifi

Najafi

2019

Sci Rep

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Projection microstereolithography (PµSL) is a promising additive manufacturing technique due to its low cost, accuracy, speed, and also the diversity of the materials that it can use. Recently it has shown great potentials in various applications such as microfluidics, tissue engineering, micro-optics, biomedical microdevices, and so on. However, studies on PµSL are still ongoing in terms of the quality and accuracy of the construction process, which particularly affect the fabrication of complex 3D microstructures and make it attractive enough to be considered for commercial applications. In this paper, a compact LED-based PµSL 3D printer for the fabrication of 3D microstructures was developed, and the effective parameters that influence the quality of construction were thoroughly investigated and optimized. Accordingly, a customized optical system, including illumination optics and projection optics, was designed using optical engineering principles. This custom 3D printer was proposed for the PµSL process, which besides improving the quality of construction, led to the reduction of the size of the device, its cost-effectiveness, and the repeatability of its performance. To demonstrate the performance of the fabricated device, a variety of complex 3D microstructures such as porous, hollow, helical, and self-support microstructures were constructed. In addition, the repeatability of the device was assessed by fabricating microstructure arrays. The device performance showed that the lateral accuracy of printing was better than 5 μm, and the smallest thickness of the printed layer was 1 μm. Moreover, the maximum printable size of the device was 6.4 mm × 4 mm × 40 mm.

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Section: Introductionmentioning

confidence: 99%

A compact LED-based projection microstereolithography for producing 3D microstructures

Behroodi

Latifi

Najafi

2019

Sci Rep

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“…Because PPF is highly viscous, dilution in a solvent such as DEF is necessary for control over feature size [125]. Besides substrates for tissue engineering and cell culturing, microneedles with a tip radius of~50 µm for drug delivery have been fabricated using PPF and µ-SLA [126]. [129]) all used as reinforcement materials.…”

Section: Polypropylene Fumarate (Ppf)mentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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“…• Different teams developed microneedles made by micro-SLA, aiming at applications such as transdermal drug delivery [80]. • Different teams developed microneedles made by micro-SLA, aiming at applications such as transdermal drug delivery [80].…”

Section: Microstereolithography Components For Biomedical Applicationsmentioning

confidence: 99%

Microstereolithography

Bertsch¹,

Renaud²

2016

Three-Dimensional Microfabrication Using Two-Photon Polymerization

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Development of DMD-based micro-stereolithography apparatus for biodegradable multi-material micro-needle fabrication

Cited by 19 publications

References 16 publications

A compact LED-based projection microstereolithography for producing 3D microstructures

A compact LED-based projection microstereolithography for producing 3D microstructures

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Microstereolithography

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