Development of contrast digital mammography

Skarpathiotakis, Mia; Yaffe, Martin J.; Bloomquist, Aili K.; Rico, Dan; Muller, Serge; Rick, Andreas; Jeunehomme, Fanny

doi:10.1118/1.1510128

Cited by 105 publications

(77 citation statements)

References 23 publications

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“…In temporal subtraction breast X-ray imaging, one pre-contrast and one (or more) post-contrast time-points are acquired using a spectrum predominantly above the K-edge of iodine (33.2 keV) [9][10][11][12]. Pre-and post-contrast images are then subtracted logarithmically, yielding iodine-enhanced images.…”

mentioning

confidence: 99%

Dual-energy contrast-enhanced digital breast tomosynthesis – a feasibility study

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Gavenonis²,

Currivan³

et al. 2010

BJR

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ABSTRACT. Contrast-enhanced digital breast tomosynthesis (CE-DBT) is a novel modality for imaging breast lesion morphology and vascularity. The purpose of this study is to assess the feasibility of dual-energy subtraction as a technique for CE-DBT (a temporal subtraction CE-DBT technique has been described previously). As CE-DBT evolves, exploration of alternative image acquisition techniques will contribute to its optimisation. Evaluation of dual-energy CE-DBT was conducted with Institutional Review Board (IRB) approval from our institution and in compliance with federal Health Insurance Portability and Accountability Act (HIPAA) guidelines. A 55-year old patient with a known malignancy in the right breast underwent imaging with MRI and CE-DBT. CE-DBT was performed in the medial lateral oblique view with a DBT system, which was modified under IRB approval to allow high-energy image acquisition with a 0.25 mm Cu filter. Image acquisition occurred via both temporal and dual-energy subtraction CE-DBT. Between the pre-and post-contrast DBT image sets, a single bolus of iodinated contrast agent (1.0 ml kg -1 ) was administered, followed by a 60 ml saline flush. The contrast agent and saline were administrated manually at a rate of ,2 ml s -1 . Images were reconstructed using filtered-back projection and transmitted to a clinical PACS workstation. Dual-energy CE-DBT was shown to be clinically feasible. In our index case, the dual-energy technique was able to provide morphology and kinetic information about the known malignancy. This information was qualitatively concordant with that of CE-MRI. Compared with the temporal subtraction CE-DBT technique, dual-energy CE-DBT appears less susceptible to motion artefacts. Breast tumour growth and metastasis are accompanied by the development of new blood vessels that have an abnormally increased permeability [1]. As a result, the absorption of vascular contrast agents in malignant breast tissue is often different to that in benign and normal tissues. Today, contrast-enhanced MRI (CE-MRI), which uses a gadolinium chelate as a vascular contrast agent, is the standard for vascular imaging of breast cancers [2][3][4][5][6][7]. Breast lesion characterisation with CE-MRI relies on a combination of the analysis of the morphological features of the lesion and the vascular enhancement kinetics.Preliminary studies have demonstrated that contrastenhanced digital breast tomosynthesis (CE-DBT) using an iodinated vascular contrast agent has the potential to demonstrate morphology and vascular enhancement information concordant with that of CE-MRI [8]. As the clinical uses of CE-MRI continue to expand, investigation into a potential alternative such as CE-DBT (which is projected to be less costly and more widely available than MRI) may also increase in importance.Two CE X-ray imaging techniques have been proposed: temporal and dual-energy subtraction. In temporal subtraction breast X-ray imaging, one pre-contrast and one (or more) post-contrast time-points are acquired using a spectrum pred...

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mentioning

confidence: 99%

Dual-energy contrast-enhanced digital breast tomosynthesis – a feasibility study

Carton

Gavenonis²,

Currivan³

et al. 2010

BJR

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“…Skarpathiotakis et al [51] previously used computer modeling and the processing of contrast-enhanced digital mammography images and found the attainable concentration of a contrast medium detectable with this technique [52].…”

Section: Contrast-enhanced Mammography and Tomosynthesismentioning

confidence: 99%

How Can New Imaging Modalities Help in the Practice of Radiology?

et al. 2017

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The purpose of this article was to provide an up-to-date review on the spectrum of new imaging applications in the practice of radiology. New imaging techniques have been developed with the objective of obtaining structural and functional analyses of different body systems. Recently, new imaging modalities have aroused the interest of many researchers who are studying the applicability of these modalities in the evaluation of different organs and diseases. In this review article, we present the efficiency and utilization of current imaging modalities in daily radiological practice.

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“…In order to erase these backgrounds, the image in Fig. 6(b) was logarithmically subtracted [1,2] from that in Fig. 6(a).…”

Section: Application Of Strong Attenuation Above the K-absorption Edgementioning

confidence: 99%

“…1, if the energy of the X-rays is slightly above the absorption edge of the element of interest, we obtain very high attenuation by the element, and therefore very high contrast in the transmission image. One can adjust the spectra of X-ray tubes by changing the tube voltages, the anode materials, and the filters [1,2]. However, spectra of X-ray tubes always suffer from broad Bremsstrahlung continua.…”

Section: Introductionmentioning

confidence: 99%

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Imaging by using proton-induced quasi-monochromatic X-ray emission

Iwatani¹,

Kaneko²,

Hasegawa³

et al. 2004

Science and Technology of Advanced Materials

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Quasi-monochromatic X-ray emission induced by MeV-proton bombardment onto metallic targets was applied to radiography of small samples. The X-ray energy was adjusted in the range of z4-23 keV by changing the target material. The radiograms were recorded on an imaging plate. A small phantom made of Lucite was prepared for the test of photography using a contrast medium (RuCl 3 $H 2 O; ruthenium chloride). To clearly observe the image of the contrast agent, the photon energy was chosen to be 23.17 keV (Cd Ka) which is slightly above the K-absorption edge of Ru at 22.12 keV. Only the image of the contrast agent was successfully extracted by subtracting the image taken by 21.18-keV X-rays (Pd Ka) from that obtained by the 23.17-keV photons. Also images of a small fish sample were taken using a point-like X-ray source excited by a proton microbeam with a diameter of z10 mm. In this experiment, the X-ray energy was adjusted to 4.51 keV (Ti Ka) to obtain a strong attenuation by Ca in the bones. A fine structure of the bones in the thin caudal fin (!100 mm) was highly contrasted by this method. The spatial resolution of the picture was z20 mm. Performance of the above technique based on the proton-induced quasimonochromatic X-ray emission is discussed in comparison to conventional methods. q

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Development of contrast digital mammography

Cited by 105 publications

References 23 publications

Dual-energy contrast-enhanced digital breast tomosynthesis – a feasibility study

Dual-energy contrast-enhanced digital breast tomosynthesis – a feasibility study

How Can New Imaging Modalities Help in the Practice of Radiology?

Imaging by using proton-induced quasi-monochromatic X-ray emission

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