Development of combi-pills using the coupling of semi-solid syringe extrusion 3D printing with fused deposition modelling

Zhang, Bin; Teoh, Xin-Yi; Yan, Jiongyi; Gleadall, Andrew; Belton, Peter; Bibb, Richard; Qi, Sheng

doi:10.1016/j.ijpharm.2022.122140

Cited by 20 publications

(10 citation statements)

References 36 publications

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“…In this study, tablets with three different infill densities (50%, 75%, and 100%) were manufactured using the semi-solid extrusion 3D printing method. As shown in Figure 11 , the BSA release rate increased with the reduction of infill density, which is consistent with the results reported among other studies [ 41 , 42 ]. The release fraction was amplified by ~1.8x at 10 h when the infill density dropped from 100% to 50%.…”

Section: Resultssupporting

confidence: 92%

Development of pH-Responsive Polypills via Semi-Solid Extrusion 3D Printing

Wang

Zhu

et al. 2023

Bioengineering

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The low bioavailability of orally administered drugs as a result of the instability in the gastrointestinal tract environment creates significant challenges to developing site-targeted drug delivery systems. This study proposes a novel hydrogel drug carrier using pH-responsive materials assisted with semi-solid extrusion 3D printing technology, enabling site-targeted drug release and customisation of temporal release profiles. The effects of material parameters on the pH-responsive behaviours of printed tablets were analysed thoroughly by investigating the swelling properties under both artificial gastric and intestinal fluids. It has been shown that high swelling rates at either acidic or alkaline conditions can be achieved by adjusting the mass ratio between sodium alginate and carboxymethyl chitosan, enabling site-targeted release. The drug release experiments reveal that gastric drug release can be achieved with a mass ratio of 1:3, whilst a ratio of 3:1 allows for intestinal release. Furthermore, controlled release is realised by tuning the infill density of the printing process. The method proposed in this study can not only significantly improve the bioavailability of oral drugs, but also offer the potential that each component of a compound drug tablet can be released in a controlled manner at a target location.

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Section: Resultssupporting

confidence: 92%

Development of pH-Responsive Polypills via Semi-Solid Extrusion 3D Printing

Wang

Zhu

et al. 2023

Bioengineering

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“…Yet other group melt powdered materials like selective laser sintering to obtain 3D parts [152]. A few AM techniques are based on melting of wired materials like the materials to develop the layers such as FDM [153]. Generally, material in liquid form results in better deposition which in turn implies that polymers and their derivatives offer convenience which can be accounted to lower processing or melting temperatures during process.…”

Section: Raw Materials State For Am Processmentioning

confidence: 99%

A review of various materials for additive manufacturing: Recent trends and processing issues

Srivastava

Rathee²,

Patel³

et al. 2022

Journal of Materials Research and Technology

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“…Thus, in order to translate the technology to clinical practice, a fundamental understanding of the key principles of optimising the printability of SSE inks is needed to guide new product development. 22,27,43…”

Section: Introductionmentioning

confidence: 99%

“…HPMC, PVP and SiO 2 44–46 were selected in this study. As a ramification of our previous study where HPMC-PVP was identified as an ideal excipient combination in semisolid extrusion-based 3D printing, 22 therefore, this study aims to investigate the effect of additive and APIs incorporation on the printability and drug release performance of 3D printed tablets. In this study, additive SiO 2 as the disintegrant and two APIs with different levels of water solubilities ( i.e.…”

Section: Introductionmentioning

confidence: 99%