Development of Colorectal Tumors in Colonoscopic Surveillance in Lynch Syndrome

Mecklin∥, Jukka–Pekka; Aarnio, Markku; Läärä, Esa; Kairaluoma, Matti I.; Pylvänäinen, Kirsi; Peltomäki, Païvi; Aaltonen, Lauri A.; Järvinen, Heikki

doi:10.1053/j.gastro.2007.08.019

Cited by 128 publications

(87 citation statements)

References 25 publications

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“…The recommended screening protocol for Lynch syndrome includes colonoscopy every 1-2 years beginning at 20-25 years of age [14], a strategy shown to significantly reduce morbidity and mortality in a large cohort of patients with 15 years of follow up. In this study, the risk of CRC was 35% in men and 22% in women [15] with a 65% decrease in CRC related mortality [16]. Screening colonoscopy should begin between ages 10 and 12 in individuals with FAP with subsequent colectomy once the polyp burden becomes too great for endoscopic management [17].…”

Section: Genetic Testing In Gastrointestinal Cancersmentioning

confidence: 71%

Genetic counselling and genetic testing in hereditary gastrointestinal cancer syndromes

Raymond

Everett

2009

Best Practice & Research Clinical Gastroenterology

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Section: Genetic Testing In Gastrointestinal Cancersmentioning

confidence: 71%

Genetic counselling and genetic testing in hereditary gastrointestinal cancer syndromes

Raymond

Everett

2009

Best Practice & Research Clinical Gastroenterology

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“…Patients with Lynch syndrome have been shown to be at a high risk of developing colorectal cancer, including those with remaining large intestine after surgery for colorectal cancer, and regular and lifelong endoscopic surveillance with the aim of any resecting precancerous adenomas and early detection of colorectal cancer is required 225,226) . Many studies have recommended that surveillance be started at the age of 20-25 years 196) .…”

Section: Cq29: Is Surveillance By Colonoscopy Effective In Patients Wmentioning

confidence: 99%

Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version)

Ishida

Yamaguchi

Tanakaya

et al. 2018

J Anus Rectum Colon

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Hereditary colorectal cancer accounts for less than 5% of all colorectal cancer cases. Some of the unique characteristics that are commonly encountered in cases of hereditary colorectal cancer include early age at onset, synchronous/metachronous occurrence of the cancer, and association with multiple cancers in other organs, necessitating different management from sporadic colorectal cancer. While the diagnosis of familial adenomatous polyposis might be easy because usually 100 or more adenomas that develop in the colonic mucosa are in this condition, Lynch syndrome, which is the most commonly associated disease with hereditary colorectal cancer, is often missed in daily medical practice because of its relatively poorly defined clinical characteristics. In addition, the disease concept and diagnostic criteria for Lynch syndrome, which was once called hereditary non‐polyposis colorectal cancer, have changed over time with continual research, thereby possibly creating confusion in clinical practice. Under these circumstances, the JSCCR Guideline Committee has developed the “JSCCR Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (HCRC)," to allow delivery of appropriate medical care in daily practice to patients with familial adenomatous polyposis, Lynch syndrome, or other related diseases. The JSCCR Guidelines 2016 for HCRC were prepared by consensus reached among members of the JSCCR Guideline Committee, based on a careful review of the evidence retrieved from literature searches, and considering the medical health insurance system and actual clinical practice settings in Japan. Herein, we present the English version of the JSCCR Guidelines 2016 for HCRC.

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“…This decision should be individualized and discussed with each patient (considering pros and cons, based on age, comorbidity, etc.) [23]. In order to optimize the performance of colonoscopy surveillance in LS patients, new endoscopic techniques have been evaluated in recent years.…”

Section: Lynch Syndromementioning

confidence: 99%