Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections

Li, Dan; Kumari, Beena; Makabenta, Jessa Marie; Tao, Bailong; Qian, Kun; Mei, Xifan; Rotello, Vincent M.

doi:10.1039/d0tb00549e

Cited by 21 publications

(15 citation statements)

References 157 publications

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“…Nanoclusters (NCs) of coinage metal represent important options for pursuing fundamental studies of nanoscale materials and for realizing their potential practical applications . The precision and reproducibility with which the NCs could be synthesized in liquid media and the established knowledge about their structure and electronic states being correlated to their properties offer advantages that are unique and atomically tunable. , In that respect, the NCs of Au and Ag have been explored rather extensively especially through the utilization of their photoluminescence and catalytic properties. − Furthermore, the organic ligands that stabilize the NCs add to the versatility of their properties .…”

Section: Introductionmentioning

confidence: 99%

Delayed Dual Emission of Two-Dimensional Copper Nanocluster Assembly

Das

Chattopadhyay

2022

J. Phys. Chem. C

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We report the formation of two-dimensional single crystalline nanosheets of Cu nanoclusters by complexation with Zn metal ion. The so-formed crystals, with augmented prompt photoluminescence and lifetime, exhibited delayed photoluminescence at room temperature with a quantum yield of 83.6 ± 1.3% and a lifetime of 26.4 ± 0.7 μs. The delayed photoluminescence lifetime was further increased to 145.0 ± 7.7 μs by surface functionalization of the nanosheets with 8-hydroxyquinoline. The surface complexation led to the generation of a new emitting channel in the crystal, which thus formed a single nanocomponent with dual channel emitting prompt and delayed near-white light.

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Section: Introductionmentioning

confidence: 99%

Delayed Dual Emission of Two-Dimensional Copper Nanocluster Assembly

Das

Chattopadhyay

2022

J. Phys. Chem. C

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“…Both drug-resistant and toxic problems are relieving [ 8 ]. Recently, CDs [ 9 , 10 ] and nanoclusters (NCs) [ 11 ] are well applied for combating bacterial infections because they are biocompatible [ 12 ], active [ 13 ], and can be easily cleaned by circulations due to the ultra-small sizes [ 14 , 15 ]. Especially, researchers have found that CDs show excellent free radical scavenging ability, which can be stronger than many traditional anti-infection drugs [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Zhuang

Li²,

Daoyong³

et al. 2021

Nanoscale Res Lett

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Carbon dots (CDs) have been widely used as antimicrobials due to their active surface, but some CDs suffer instability. Therefore, the relative applications such as the antibacterial activity may not be reliable for long-term use. Herein, we synthesize CDs with blue fluorescence by a hydrothermal process. Thereafter, polyethylenimine was applied for the assembly of CDs into CDs-based frameworks (CDFs). The CDFs exhibited quenched fluorescence but showed more stable properties based on the scanning electron microscope and zeta potential investigations. Both CDs and CDFs show antibacterial activity toward Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), but CDFs exhibited better antibacterial performance, and S. aureus could be completely inhibited with the minimum inhibitory concentration of 30 μg/mL. This reveals CDFs magnify both the stability and antibacterial activity, which would be more promising for practical applications. Graphic abstract

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“…Con ict of interest bacterial infections because they are biocompatible, active, and can be easily cleaned by circulations due to the ultra-small sizes. 11,12 Especially, researchers have found that CDs show excellent free radical scavenging ability, which can be stronger than many traditional anti-infection drugs. [13][14][15] However, these ultra-small antimicrobials also suffer poor stability due to the larger oxidative surface area.…”

Section: Declarationsmentioning

confidence: 99%

Assembly of Carbon Dots Into Frameworks With Enhanced Stability and Antibacterial Activity

Zhuang

et al. 2021

Preprint

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Carbon dots (CDs) have widely been used as antimicrobials due to their active surface, but they also suffer instability. Therefore the relative applications such as the antibacterial activity may not be reliable for long-term use. Herein, we synthesize CDs with blue fluorescence by a hydrothermal process. Thereafter, polyethylenimine (PEI) was applied for the assembly of CDs into CDs-based frameworks (CDFs). The CDFs exhibited quenched fluorescence but showed more stable properties based on the scanning electron microscope (SEM) and zeta potential investigations. Both CDs and CDFs show antibacterial activity toward Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), but CDFs exhibited better antibacterial performance. This reveals CDFs magnify both the stability and antibacterial activity, which would be more promising for practical applications.

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Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections

Abstract: Infections from antibiotic-resistant bacteria have caused huge economic loss and numerous deaths over the past decades.

Cited by 21 publications

References 157 publications

Delayed Dual Emission of Two-Dimensional Copper Nanocluster Assembly

Delayed Dual Emission of Two-Dimensional Copper Nanocluster Assembly

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Assembly of Carbon Dots Into Frameworks With Enhanced Stability and Antibacterial Activity

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