The degree to which ceramic coatings or thin films applied to bone-interfacing metallic implants can improve the overall performance of these implants with respect to implant fixation, wear, or corrosion relies especially on the response of these films to loading. In this study, the adhesion and fatigue properties of sol-gel zirconia films that could be reproducibly deposited onto polished Ti-6AI-4V substrates was investigated. For zirconia films on the order of 100 nm thick, a shear lag-based strain approach indicated a shear adhesion strength of approximately 275 MPa. Small variations in film thickness and substrate surface preparation had little effect on this adhesion, which was believed to be due to alkoxide molecule interactions with free hydroxyl groups on the substrate surface as well as some limited interfacial diffusion following the 500 degrees C anneal. Subsequent fatigue testing of these films in air using novel tapered rotating beam fatigue samples demonstrated their excellent fatigue characteristics, with films surviving up to 10(7) cycles, the endurance limit of the Ti-6AI-4V (approximately 635 MPa). Overall, the exceptional mechanical properties of this ZrO2/Ti-6AI-4V system along with the inherent advantages of sol-gel processing support continued studies to utilize this technology for implant surface modification.