Development of chitosan towards the self-healing and mechanically stronger biocompatible hydrogel

Afgan, Shere; Yadav, Paramjeet; Jaiswal, Sheetal; Pal, Krishtan; Kumar, Rajesh; Singh, Virendra; Koch, Biplob

doi:10.1016/j.jics.2022.100704

Cited by 3 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the AFM study of ATU, PVA, and different ratios of PVA/ATU‐based hydrogels on thin films can be viewed in real time. The topography of the thin films was captured using (Figure 3A,A′–E,E′) 23 …”

Section: Methodsmentioning

confidence: 99%

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Yadav,

Afgan,

Pal

et al. 2024

Journal of Polymer Science

Self Cite

View full text Add to dashboard Cite

Hydrogel‐based materials represent promising candidates for drug delivery. In our research, we synthesized a series of hydrogels—PVATU‐1 (2:1), PVATU‐2 (1:1), and PVATU‐3 (0.5:1)—by adjusting the poly(vinyl alcohol) (PVA) ratio while maintaining a constant ratio of allylthiourea (ATU) monomer and glutaraldehyde cross‐linker, aiming to understand their impacts on gelation. These PVATU hydrogels displayed impressive swelling in neutral conditions and exhibited visible self‐healing capabilities. Notably, PVATU‐1 shows superior mechanical strength among the variants. Surface analysis using AFM and SEM unveiled porous structures within the hydrogels, while thermal stability tests indicated their resilience up to 200°C. DSC analysis revealed minimal variation in glass transition temperatures (Tg), affirming stability. A distinct endothermic peak around 250–350°C across all hydrogels confirmed their semi‐crystalline nature, corroborated by powder XRD. Noteworthy, PVATU‐1 demonstrated optimal loading and releasing efficiency for levofloxacin, with 74.5% loading and 82.8% releasing efficiency within 18 h. Biocompatibility assessments on HeLa cells affirmed the nontoxicity of PVATU hydrogel treatments.

show abstract

Section: Methodsmentioning

confidence: 99%

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Yadav,

Afgan,

Pal

et al. 2024

Journal of Polymer Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…For MCF-7 cells, 1 × 10 4 cells were seeded in a 96-well cell culture plate and incubated overnight in a CO 2 incubator at 37 °C. 41 After the overnight incubation, the cells were treated with different dilutions (1 : 1, 1 : 5, 1 : 10, 1 : 15, and 1 : 20) of the three CSATU hydrogels for 72 hours. The spent medium was removed and 100 μL of MTT-containing medium was added to each well, which was further incubated for 2 hours.…”

Section: Methodsmentioning

confidence: 99%

Generation of multicellular tumor spheroids via 3D cell culture utilizing a hydrogel comprising chitosan and allylthiourea

Yadav¹,

Afgan²,

Singh³

et al. 2023

New J. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chitosan hydrogels are well known for their good biocompatibility owing to their composition and their network structure which closely resemble ECM [182][183][184]. Active chemical groups on chitosan may also enhance their biofunctions and performance, such as grafting functional groups with biological activities through chemical reactions which provides an exciting avenue for research in this field.…”

Section: Chitosan Hydrogels and Their Applications In Vascular Remode...mentioning

confidence: 99%

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Wang

Feng

2023

Gels

View full text Add to dashboard Cite

Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced these following aspects: advantages and progress of chitosan hydrogels in vascular regeneration hydrogels and the modification of chitosan hydrogels to improve the application in vascular regeneration. Finally, this paper discusses the prospects of chitosan hydrogels for vascular regeneration.

show abstract

Development of chitosan towards the self-healing and mechanically stronger biocompatible hydrogel

Cited by 3 publications

References 39 publications

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Generation of multicellular tumor spheroids via 3D cell culture utilizing a hydrogel comprising chitosan and allylthiourea

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Contact Info

Product

Resources

About