Co 3 O 4 -CeO 2 catalysts prepared by the co-precipitation method have been studied for the preferential oxidation of carbon monoxide in hydrogen. Effects of the cobalt contents and calcination temperature on Co 3 O 4 -CeO 2 were investigated, and the Co 3 O 4 -CeO 2 catalyst containing 80 wt.% Co 3 O 4 calcined at 350 o C exhibited the highest activity and good selectivity. The influence of the components of the feeding gas (H 2 , CO 2 and H 2 O) on the preferential oxidation of carbon monoxide had also been tested. The tested results showed that the negative effect of H 2 was much weaker than that of H 2 O and CO 2 .