Development of blood-brain barrier tight junctions in the rat cortex

Endothelial Cell-to-Cell Junctions: Adhesion and Signaling in Physiology and Pathology

“…That is, the endothelium of cerebral vessels is particularly enriched in tight junctions (Kniesel et al 1996). The functional consequence is that paracellular permeability is abolished.…”

Hypoxia Disrupts the Barrier Function of Neural Blood Vessels through Changes in the Expression of Claudin-5 in Endothelial Cells

“…7,12 The barrier properties of neural blood vessels are attributed mainly to the presence of complex tight junction networks between the endothelial cells. 13 The identification of the integral membrane molecules of tight junctions was a turning point in the research on the molecular basis of tight junctions. 14 -16 Occludin was the first identified membrane component of tight junctions, 17 but subsequent studies including gene knockout analyses demonstrated that occludin was not essential for the tight junction assembly and rather was involved in the signal transduction of endothelial cells.…”

Tight junction protein claudin 3 expression in glioma

“…This study was undertaken to understand the biological significance of altered tight junction protein expression in glioma progression. Several studies have reported the CDLN roles in forming TJs [21], conferring ionic selectivity [22] and functioning as a barrier [23], but only few reports have been published on the expression of CDLNs in glioma.…”