Development of biosynthesized silver nanoparticles based formulation for treating wounds during nursing care in hospitals

Gong, Cui-Ping; Li, Shou-Cun; Wang, Rong-Ye

doi:10.1016/j.jphotobiol.2018.04.030

Cited by 55 publications

(23 citation statements)

References 17 publications

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“…Physically or chemically induced cutaneous wounds may significantly disturb skin structural and functional integrity at different stages, leading to permanent disability or even death, depending on the severity of the injury [ 169 ]. In the past few years, wound infections caused by opportunistic pathogenic microorganism became an important issue during current healthcare practice [ 170 ]. The ultimate tendency and ideal desideratum for infected-wound management is represented by fast tissue-recovery processes, accompanied by maximal functionality restoration and minimal scar-tissue formation [ 171 ].…”

Section: Silver Nanoparticles For Wound Healingmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

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Section: Silver Nanoparticles For Wound Healingmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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“…In BALB/C mice with a thermal injury, silver NPs (14 nm) coatings on bandages reduced inflammation and scarring, eliminated bacterial growth, and accelerated the healing [97]. Gong et al also developed biosynthesized AgNP based ointments, demonstrating the efficacy of AgNPs in upgrading wound healing activity and improving wound contractions in albino rats [98]. The results obtained by Adibhesami et al demonstrated in vivo the positive effect of AgNPs on mice wound inoculated with Staphylococcus aureus , the most common pathogen involved in wound infections.…”

Section: The Role Of Silver In Wound Healingmentioning

confidence: 99%

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

2019

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Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in the European Union and European Economic Area (EEA) can be estimated as the cumulative burden of tuberculosis, influenza, and human immunodeficiency virus (HIV). In wound management, the control of infections represents a crucial issue and a multi-billion dollar industry worldwide. For diabetic wounds ulcers, in particular, infections are related to the majority of amputations in diabetic patients, which today represent an increasing number of the elderly. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance with high resistance to conventional antimicrobial therapies. There is an urgent need for novel anti-biofilm strategies and novel antimicrobial agents and, in this scenario, silver nanotechnology has received tremendous attention in recent years in therapeutically enhanced healthcare. Due to its intrinsic therapeutic properties and the broad-spectrum antimicrobial efficacy, silver nanoparticles have opened new horizons towards novel approaches in the control of infections in wound healing. This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.

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“…Depending on the severity of the physical or chemical injury, the wound may hurt for a long time or even be lethal [123]. When caring for a wound, it is important to prevent it from drying out and to take measures against bacterial infection [124]. Wound dressings are used to maintain a humid environment, and disinfection and antibiotic treatment are measures against infection.…”

Section: Other Medical Applicationsmentioning

confidence: 99%

Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers

Nakamura

Sato

et al. 2019

IJMS

203

115

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Silver is easily available and is known to have microbicidal effect; moreover, it does not impose any adverse effects on the human body. The microbicidal effect is mainly due to silver ions, which have a wide antibacterial spectrum. Furthermore, the development of multidrug-resistant bacteria, as in the case of antibiotics, is less likely. Silver ions bind to halide ions, such as chloride, and precipitate; therefore, when used directly, their microbicidal activity is shortened. To overcome this issue, silver nanoparticles (Ag NPs) have been recently synthesized and frequently used as microbicidal agents that release silver ions from particle surface. Depending on the specific surface area of the nanoparticles, silver ions are released with high efficiency. In addition to their bactericidal activity, small Ag NPs (<10 nm in diameter) affect viruses although the microbicidal effect of silver mass is weak. Because of their characteristics, Ag NPs are useful countermeasures against infectious diseases, which constitute a major issue in the medical field. Thus, medical tools coated with Ag NPs are being developed. This review outlines the synthesis and utilization of Ag NPs in the medical field, focusing on environment-friendly synthesis and the suppression of infections in healthcare workers (HCWs).

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Development of biosynthesized silver nanoparticles based formulation for treating wounds during nursing care in hospitals

Cited by 55 publications

References 17 publications

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers

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