Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers

Nakamura, Shingo; Sato, Masahiro; Sato, Yoko; Ando, Naoto; Takayama, T.; Fujita, Masanori; Ishihara, Masayuki

doi:10.3390/ijms20153620

Cited by 201 publications

(135 citation statements)

References 139 publications

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“…Daily wound cleaning with HClO solution (pH 6.5) for 12 days decreased the Pseudomonas aeruginosa (P. aeruginosa) bioburden of infected wounds in db/db diabetic mice but wound healing was delayed [18]. Limiting disinfection treatment with both HClO and chitin-nanofiber sheet-immobilized silver nanoparticles (CNFS/Ag NPs) to 3 days [19][20][21] may suppress these negative effects on wound repair [22]. We previously showed that treating P. aeruginosa-infected wounds on hairless rats with BiSCaO suspension (0.2 wt%, pH 12.3) once daily for 3 days and covering the wound with CNFS significantly decreased the P. aeruginosa bioburden and enhanced healing [23].…”

Section: Introductionmentioning

confidence: 99%

Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity

et al. 2020

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Bioshell calcium oxide (BiSCaO) exhibits deodorizing properties and broad microbicidal activity. In this study, we examined possible utility of BiSCaO Water for that purpose. BiSCaO Water was prepared by adding 10 wt% BiSCaO to clean water and gently collecting the supernatant in a bottle. The same volume of clean water was gently poured onto the BiSCaO precipitate and the supernatant was gently collected in a bottle; this process was repeated fifty times. The produced BiSCaO Water contained nanoparticles (about 400–800 nm) composed of smaller nanoparticles (100–200 nm), and was colorless and transparent, with a pH > 12.7. In vitro assays demonstrated that BiSCaO Water eliminated more than 99.9% of influenza A (H1N1) and Feline calicivirus, Escherichia coli such as NBRC 3972 and O-157:H7, Pseudomonas aeruginosa, Salmonella, and Staphylococcus aureus within 15 min. We compared BiSCaO Water with the other microbicidal reagents such as ethanol, BiSCaO, BiSCa(OH)2 suspensions, povidone iodine, NaClO, BiSCaO dispersion and colloidal dispersion with respect to deodorization activity and microbicidal efficacy. The results showed that BiSCaO Water was a potent reagent with excellent deodorization and disinfection activities against pathogenic bacteria and viruses (including both enveloped and nonenveloped viruses).

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Section: Introductionmentioning

confidence: 99%

Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity

et al. 2020

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“…The antibacterial effects of AgNPs partly depend on their solubility. In the solution, AgNPs will release a high concentration of Ag ions, which can anchor the protein groups on the cell wall of bacteria and cause protein denaturation to form pores, eventually leading to increased permeability of the cell membrane and an imbalance of homeostasis [60]. In addition, studies have reported that AgNPs entering cells may directly damage DNA, RNA, and chromatin [61,62].…”

Section: Metal Nmsmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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“…Other noble metals have been used successfully for virus diagnosis and detection. Specifically, AgNPs are among the most employed plasmonic nanostructures for biomedical applications [ 135 , 231 , 232 , 233 , 234 ]. The main advantage of AgNPs lies in their higher extinction coefficient when compared to AuNPs.…”

Section: Diagnostics and Biosensors For Covid-19mentioning

confidence: 99%

Biomedical Science to Tackle the COVID-19 Pandemic: Current Status and Future Perspectives

et al. 2020

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The coronavirus infectious disease (COVID-19) pandemic emerged at the end of 2019, and was caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has resulted in an unprecedented health and economic crisis worldwide. One key aspect, compared to other recent pandemics, is the level of urgency, which has started a race for finding adequate answers. Solutions for efficient prevention approaches, rapid, reliable, and high throughput diagnostics, monitoring, and safe therapies are needed. Research across the world has been directed to fight against COVID-19. Biomedical science has been presented as a possible area for combating the SARS-CoV-2 virus due to the unique challenges raised by the pandemic, as reported by epidemiologists, immunologists, and medical doctors, including COVID-19’s survival, symptoms, protein surface composition, and infection mechanisms. While the current knowledge about the SARS-CoV-2 virus is still limited, various (old and new) biomedical approaches have been developed and tested. Here, we review the current status and future perspectives of biomedical science in the context of COVID-19, including nanotechnology, prevention through vaccine engineering, diagnostic, monitoring, and therapy. This review is aimed at discussing the current impact of biomedical science in healthcare for the management of COVID-19, as well as some challenges to be addressed.

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Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers

Cited by 201 publications

References 139 publications

Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity

Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Biomedical Science to Tackle the COVID-19 Pandemic: Current Status and Future Perspectives

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