Development of biodegradable Zn–1Mg–0.1RE (RE = Er, Dy, and Ho) alloys for biomedical applications

Tong, Xian; Zhang, Dechuang; Lin, Jixing; Dai, Yongnian; Luan, Yanan; Sun, Quanxiang; Shi, Zhanbiao; Wang, Kun; Gao, Yao; Lin, Jianguo; Li, Yuncang; Dargusch, Matthew S.; Wen, Cuie

doi:10.1016/j.actbio.2020.09.036

Cited by 66 publications

(24 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The corrosion resistance of Mg-light REE alloys was normally better compared to Mg-heavy REE alloys. [124][125][126] Al With increasing Al-content (the maximum is reached at solubility limit of 12.7 wt.% Al), the corrosion rate of homogeneous α-phase decreases. [127] Ca is the main part of human bones and is vital for the life of human beings [128].…”

Section: LImentioning

confidence: 99%

Biodegradable Magnesium Biomaterials—Road to the Clinic

Amukarimi

Mozafari

2022

Bioengineering

View full text Add to dashboard Cite

In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.

show abstract

Section: LImentioning

confidence: 99%

Biodegradable Magnesium Biomaterials—Road to the Clinic

Amukarimi

Mozafari

2022

Bioengineering

View full text Add to dashboard Cite

show abstract

“…In addition, the relatively low creep resistance, low fatigue strength, high susceptibility, and low-temperature recrystallization of Zn has limited its use for the development of implant materials. In recent years, many alloys or composites of Zn-based biodegradable materials have been established with improved biocompatibility, bio-corrosion, and mechanical properties [ 59 , 60 , 61 , 62 , 63 ]. Many essential trace elements for the human body have been used for making Zn-based biodegradable alloys, and many types of reinforcement materials have been used for making Zn composites [ 64 , 65 , 66 , 67 ].…”

Section: Zn-based Biomaterialsmentioning

confidence: 99%

Recent Developments in Zn-Based Biodegradable Materials for Biomedical Applications

Hussain

Ullah

Raza

et al. 2022

JFB

View full text Add to dashboard Cite

Zn-based biodegradable alloys or composites have the potential to be developed to next-generation orthopedic implants as alternatives to conventional implants to avoid revision surgeries and to reduce biocompatibility issues. This review summarizes the current research status on Zn-based biodegradable materials. The biological function of Zn, design criteria for orthopedic implants, and corrosion behavior of biodegradable materials are briefly discussed. The performance of many novel zinc-based biodegradable materials is evaluated in terms of biodegradation, biocompatibility, and mechanical properties. Zn-based materials perform a significant role in bone metabolism and the growth of new cells and show medium degradation without the release of excessive hydrogen. The addition of alloying elements such as Mg, Zr, Mn, Ca, and Li into pure Zn enhances the mechanical properties of Zn alloys. Grain refinement by the application of post-processing techniques is effective for the development of many suitable Zn-based biodegradable materials.

show abstract

“…The choice of blending element is crucial to ensure the resulting alloy possesses sufficient mechanical strength, suitable degradation behavior, and acceptable biocompatibility. Various alloying elements have been explored, including Mg [ 7 , [10] , [11] , [12] , [13] ], strontium (Sr) [ 7 , 14 , 15 ], calcium (Ca) [ 7 , 14 ], lithium (Li) [ 16 , 17 ], and rare earth elements [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%