Development of biocompatible glycodynameric hydrogels joining two natural motifs by dynamic constitutional chemistry

Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control

“…Three series of hydrogels based on chitosan and cinnamaldehyde were synthetized by imination reaction followed by the self-ordering of the newly formed imine units into clusters playing the role of chitosan crosslinkers. [8][9][10][11][12][13][14][15] Scheme 1 represents the obtaining of the studied hydrogels,…”

“…[8][9][10][11][12][13][14][15] It was demonstrated that using this strategy, biocompatible hydrogels could be successfully obtained, because the method allows using a large variety of monoaldehyde crossslinkers. 9,10,15 One important feature of the hydrogels is their ability to absorb large amounts of water or biologic fluids, which prompt them to mimic the tissues, or to encapsulate large amounts of drug to create drug delivery systems. 16 The ability of swelling is close related to the morphology of the hydrogels, so that, many efforts were dedicated to control the hydrogel morphology and consequently to control the swelling.…”

Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels

“…Given that the space is fractal and using the equation (5) for the metric tensor in polymeric matter, we must have for the integrant of equation (8) the expression: (9) where we use the notation !for the gradient in fractal coordinates. The Euler equations corresponding to the functional (8) are: (10) The last two equations represent a harmonic application from the fractal space to the fractal hyperbolic plane. As a consequence of those equations we have, as one can easily verify, the equation: (11) This means that the scalar quantity under the differential gradient operator is constant, real and always positive, being a sum of two squares of some real quantities.…”

“…Many attempts were pursued in order to overcome this drawback, consisting in new crosslinkers, or even in new crosslinking strategies . An interesting approach for preparing in vivo biocompatible hydrogels was developed by hydrogelation of chitosan with citral, a natural compound extracted from lemon grass [10]. The hydrogels proved porous morphology with low diameter pores, moderate swelling in physiological pH while their shape was well preserved, these being important features for local therapies.…”

Improving the Shelf-Life of Fruits Using Chitosan and Chitosan-Based Glycodynamer Coatings

“…The glycodynameric feature (reversible/dynamic covalent bonds) is determined by the competition between the imine formation (amino groups of chitosan-aldehyde group of citral) with citral aliphatic side chains' self-organization into supramolecular layered architectures [2]. The resulted glycodynameric structures combine excellent mechanical properties with stimuli-controlled transitions [3]. Two types of film coating were applied on berry fruits, chitosan coating and glycodynamer coating.…”