Development of antimicrobial colloidal silver incorporated lyophilized biopolymer wafers for wound care

Tabassum, Asma; Furtado, Sharon; Srinivasan, Bharath

doi:10.1016/j.wndm.2018.04.001

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…These wafers possess the unique ability to incorporate drugs within their matrix. They exhibit a remarkable capacity to absorb fluids, including excessive exudates, while also facilitating the gradual diffusion of the drug within the wound bed [ 142 ].…”

Section: Classification Of the Dressings By Physical Formmentioning

confidence: 99%

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Prete,

Dattilo,

Patitucci

et al. 2023

JFB

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Biomaterials are at the forefront of the future, finding a variety of applications in the biomedical field, especially in wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try to heal through a series of interconnected processes involving several initiators and mediators such as cytokines, macrophages, and fibroblasts. The combination of biopolymers with wound healing properties may provide opportunities to synthesize matrices that stimulate and trigger target cell responses crucial to the healing process. This review outlines the optimal management and care required for wound treatment with a special focus on biopolymers, drug-delivery systems, and nanotechnologies used for enhanced wound healing applications. Researchers have utilized a range of techniques to produce wound dressings, leading to products with different characteristics. Each method comes with its unique strengths and limitations, which are important to consider. The future trajectory in wound dressing advancement should prioritize economical and eco-friendly methodologies, along with improving the efficacy of constituent materials. The aim of this work is to give researchers the possibility to evaluate the proper materials for wound dressing preparation and to better understand the optimal synthesis conditions as well as the most effective bioactive molecules to load.

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Section: Classification Of the Dressings By Physical Formmentioning

confidence: 99%

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Prete,

Dattilo,

Patitucci

et al. 2023

JFB

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“…Nevertheless, released Ca 2+ into the wound is helping the clotting mechanism in the course of the first stage of wound healing [147]. Alginate dressings are very absorbent (15-20 times their weight in fluid), biodegradable, and non-adherent [63,148].…”

Section: Alginate Dressingsmentioning

confidence: 99%

“…As a result of their functional groups' alginate can be efficiently mixed with different biopolymers and consequently generating cross-linked network structure. These cross-linked network structures could improve the physical stability of the wound dressing material and also furnish a moist wound environment [51,147].…”

Section: Alginate Dressingsmentioning

confidence: 99%

Nanomaterials for Wound Dressings: An Up-to-Date Overview

2020

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As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.

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“…The wafer formulation should be folded repeatedly in one place until breaks show the elasticity of the wafer formulation. It should withstand a minimum of 300 folds manually [48]. e. DSC studies: Differential Scanning Calorimetry (DSC) is an instrument used to measure enthalpy changes due to change in the material's physical and chemical nature due to exposure to a different temperature [3,4,48].…”

Section: Foldingmentioning

confidence: 99%

“…It should withstand a minimum of 300 folds manually [48]. e. DSC studies: Differential Scanning Calorimetry (DSC) is an instrument used to measure enthalpy changes due to change in the material's physical and chemical nature due to exposure to a different temperature [3,4,48]. f. In-vitro studies: In this study, the drug release profile of drug-loaded wafer formulation will be studying using culture plates containing human primary epidermal keratinocytes, Franz diffusion cell, and culture plates containing Gram-Positive and Gram-Negative bacterial growth [46,47,49].…”

Section: Foldingmentioning

confidence: 99%

A Review of Diabetic Foot Ulcer Infections and Lyophilized Wafer Formulation

Jani

Puri

Ubana

2021

JPRI

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Diabetic foot difficulties are the most usually occurring problems globally, resulting in economic disasters for the patients, families, and society. In patients with diabetes, the risk of emerging foot ulcers is 25% high. It has also been in the record that one lower limb amputation occurs every 30 seconds in patients with diabetes worldwide. Novel methods of drug delivery and wound dressing have to develop to solve the lower limb amputation crisis. One such novel method is "Lyophilized wafer formulation." It is an upcoming medicated dressing material that can enhance wound healing and the potential to ingest vast quantities of exudates from Chronic wounds. That can have been formulating by lyophilizing hydrogel of absorbent polymers such as Calcium Alginate, Carrageenan, Thiolated Chitosan, and plasticizer to enhance flexibility withstand the day to day mechanical stress, covered with some adhesive and protective backing layer. Unless it passes evaluation tests such as Fourier-transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM), Exudate handling property, Folding endurance, In-vitro, In-vivo drug release profile, and Gamma-irradiation sterilizes wafer formulation, and it should not administrate directly. Lyophilized wafer formulation will be the most acceptable medicated dressing material in the future that will be useful to treat the normal wound. The wound formation because of diabetic foot ulcer (DFU) infections as there will be site-specific delivery of the drug, packed with an advantage to self administer and easy termination of the drug that can achieve just by removing the wafer case of drug toxicity.

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Development of antimicrobial colloidal silver incorporated lyophilized biopolymer wafers for wound care

Cited by 7 publications

References 10 publications

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Nanomaterials for Wound Dressings: An Up-to-Date Overview

A Review of Diabetic Foot Ulcer Infections and Lyophilized Wafer Formulation

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