Development of anticancer peptides with low hemolysis, high penetrating membrane activity, certain analgesic activity and the synergistic anticancer effect

Huo, Yehong; Ma, Linhao; Zhang, Mengzhi; Niu, Mingcong; Gu, Xiulian; Zhang, Wenjie; Yan, Miaomiao; Wei, Guangcheng

doi:10.1039/d1bm02024b

Cited by 4 publications

(2 citation statements)

References 34 publications

(40 reference statements)

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“…DOX was encapsulated in the systems, which effectively improved the uptake and accumulation of DOX in drug‐resistant breast cancer cells [58] . Furthermore, DOX was loaded into P10 lipopeptide nanospheres to construct PH‐responsive P10@Dox, which can reduce side effects of DOX and improve the anticancer effect [59] …”

Section: Applications Of Peptide‐based Self‐assemblymentioning

confidence: 99%

Self‐Assembling Peptide‐Based Functional Biomaterials

Huo

Yin

et al. 2022

ChemBioChem

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Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical and physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, self-assembly morphology of peptide supramolecular architecture and their various applications, have been widely explored which have the merit of biocompatibility, easy preparation, and controllable function-ality. Herein, we introduce the latest research progress of selfassembling peptide-based nanomaterials and review their applications in biomedicine and optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this review will inspire the rational design and development of novel peptide-based functional bio-inspired materials in the future.

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Section: Applications Of Peptide‐based Self‐assemblymentioning

confidence: 99%

Self‐Assembling Peptide‐Based Functional Biomaterials

Huo

Yin

et al. 2022

ChemBioChem

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“…Anticancer peptides (ACPs) are short peptides with anticancer properties, consisting of 10–50 amino acids. They are molecular polymers between proteins and amino acids, consisting of dozens of amino acids connected by peptide bonds ( Dong et al, 2021 ; Huo et al, 2022 ). ACPs have been widely studied as one of the most reliable anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

ACP-GBDT: An improved anticancer peptide identification method with gradient boosting decision tree

Chen

et al. 2023

Front. Genet.

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Cancer is one of the most dangerous diseases in the world, killing millions of people every year. Drugs composed of anticancer peptides have been used to treat cancer with low side effects in recent years. Therefore, identifying anticancer peptides has become a focus of research. In this study, an improved anticancer peptide predictor named ACP-GBDT, based on gradient boosting decision tree (GBDT) and sequence information, is proposed. To encode the peptide sequences included in the anticancer peptide dataset, ACP-GBDT uses a merged-feature composed of AAIndex and SVMProt-188D. A GBDT is adopted to train the prediction model in ACP-GBDT. Independent testing and ten-fold cross-validation show that ACP-GBDT can effectively distinguish anticancer peptides from non-anticancer ones. The comparison results of the benchmark dataset show that ACP-GBDT is simpler and more effective than other existing anticancer peptide prediction methods.

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Development of KLA-RGD integrated lipopeptide with the effect of penetrating membrane which target the αvβ3 receptor and the application of combined antitumor

Niu

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Development of anticancer peptides with low hemolysis, high penetrating membrane activity, certain analgesic activity and the synergistic anticancer effect

Abstract: Herein, an amphiphilic cationic α-helical anticancer lipopeptide P10 with the low toxicity and high penetrating membrane activity was developed. The lipopeptide could self-assemble into stable spherical aggregates in aqueous solution,...

Cited by 4 publications

References 34 publications

Self‐Assembling Peptide‐Based Functional Biomaterials

Self‐Assembling Peptide‐Based Functional Biomaterials

ACP-GBDT: An improved anticancer peptide identification method with gradient boosting decision tree

Development of KLA-RGD integrated lipopeptide with the effect of penetrating membrane which target the αvβ3 receptor and the application of combined antitumor

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