Self‐Assembling Peptide‐Based Functional Biomaterials

Abstract

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical and physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, self-assembly morphology of peptide supramolecular architecture and their various applications, have been widely explored which have the merit of biocompatibility, easy preparation, and controllable function-ality. Herein, we introduce the latest research progress of selfassembling peptide-based nanomaterials and review their applications in biomedicine and optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this review will inspire the rational design and development of novel peptide-based functional bio-inspired materials in the future.

Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery

“…Peptides, including linear, cyclic, and hybrid, can self-assemble into a wide variety of nanostructures, such as nanotubes, nanosheets, nanorods, nanogels, nanofibers, quantum dots, nanospheres, etc. (Figure ), while peptide materials have been explored for a series of promising applications, including but not limited to several areas such as energy harvesting, catalysis, sensors, antimicrobial as well as tissue engineering agents, and drug delivery. − Peptides can play a key role in drug delivery owing to their inherent advantages and their capacity to self-assemble into nanostructures. Given the developments in the fields of biotechnology, nanotechnology, and materials chemistry, many peptides have recently been explored for their capacity to serve as nanomaterials to deliver drugs (reviewed in refs , , and ).…”

Self‐Assembly of Poly(Amino Acid)s Mediated by Secondary Conformations

“…PAAs have been extensively studied as structural or functional materials such as nanoparticles, nanotubes, and hydrogels [39] . By means of intermolecular and/or intramolecular interactions, PAAs with precise folding and stable conformations provide a novel way to determine the formation of nanoscale configurations [15,40–46] .…”

“…[16,30] PAAs have been extensively studied as structural or functional materials such as nanoparticles, nanotubes, and hydrogels. [39] By means of intermolecular and/or intramolecular interactions, PAAs with precise folding and stable conformations provide a novel way to determine the formation of nanoscale configurations. [15,[40][41][42][43][44][45][46] Compared with their disordered analogues, synthetic PAAs with ordered secondary structures, in general, have several advantageous properties, such as defined morphology or improved stability.…”

Supramolecular Self-assembly of Engineered Polyproline Helices

“…Recently, biomolecules such as peptides, lipids and DNA/RNA, have appeared in a number of reports as interesting building blocks in the synthesis of novel 2D and 3D biomaterials which assemble using supramolecular interactions. 6,[9][10][11][12][13] We are particularly interested in the use of structured peptides as supramolecular building blocks. Peptides can be prepared at scale with high purity, have canonical and non-canonical amino acids incorporated into their primary structure with high accuracy and are biocompatible.…”